| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Nutrition, University of Oslo, Institute of Basic Medical Sciences, Oslo, Norway
2 Department of Medical Genetics, Rikshospitalet University Hospital, Oslo, Norway
3 Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway
* To whom correspondence should be addressed. E-mail: fredha{at}basalmed.uio.no.
Adipokines are predominantly secretory protein hormones from adipose tissue but may originate in placenta and other organs as well. Cross-sectionally, we monitored maternal plasma concentration of adiponectin, resistin and leptin and their mRNA expression in abdominal subcutaneous adipose tissue and placenta from preeclamptic (PE; n = 15) and healthy pregnant (HP; n = 23) women undergoing caesarean section. The study groups were similar in age and body mass index (BMI), whereas homeostatic model assessment for insulin resistance (HOMA-IR) tended to be higher in the PE group. In fasting plasma samples, the PE group had higher concentrations (mean ± SE) of adiponectin (18.3 ± 2.2 vs. 12.2 ± 1.1 µg/mL, P = 0.011), resistin (5.68 ± 0.41 vs. 4.65 ± 0.32 ng/mL, P = 0.028) and leptin (34.4 ± 3.2 vs. 22.7 ± 2.1 ng/mL, P = 0.003), as compared to the HP group. Adiponectin and leptin concentrations were still different between PE and HP after controlling for BMI and HOMA-IR, whereas resistin concentrations differed only after controlling for BMI but not HOMA-IR. We found similar mean mRNA levels of adiponectin, resistin and leptin in abdominal subcutaneous adipose tissue in PE and HP women. When pooling data from PE and HP women, resistin mRNA levels in adipose tissue correlated with HOMA-IR (r = 0.470; P = 0.012), also after controlling for BMI and pregnancy duration. Resistin mRNA levels in placenta were not significantly different between PE and HP, whereas leptin mRNA levels were higher in PE placenta compared to HP. Thus, increased plasma concentrations of adiponectin and resistin in preeclampsia may not relate to altered expression levels in adipose tissue and placenta, whereas both plasma and placenta mRNA levels of leptin are increased in preeclampsia.
This article has been cited by other articles:
|
|
 |
|
  M. Fasshauer, T. Waldeyer, J. Seeger, S. Schrey, T. Ebert, J. Kratzsch, U. Lossner, M. Bluher, M. Stumvoll, R. Faber, et al. Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function Eur. J. Endocrinol., February 1, 2008; 158(2): 197 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Troisi, N. Potischman, and R. N. Hoover Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1700 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Herse, R. Dechend, N. K. Harsem, G. Wallukat, J. Janke, F. Qadri, L. Hering, D. N. Muller, F. C. Luft, and A. C. Staff Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia Hypertension, March 1, 2007; 49(3): 604 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-M. Alexe, G. Syridou, and E. Th. Petridou Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes Clin. Med. Res., December 1, 2006; 4(4): 326 - 335. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
