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Articles in PresS, published online ahead of print April 2, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00007.2002
Submitted on January 8, 2002
Accepted on March 31, 2002
* To whom correspondence should be addressed. E-mail: bieschrijv{at}yahoo.com.
Various growth factors and cytokines have been implicated in different forms of kidney enlargement. Vascular endothelial growth factor (VEGF) is essential for normal renal development and plays a role in diabetic glomerular enlargement. To explore a possible role for VEGF in compensatory renal changes following uninephrectomy, we examined the effect of a neutralizing VEGF-antibody (VEGF-ab) on glomerular volume and kidney weight in mice treated for 7 days. Serum and kidney insulin-like growth factor I (IGF-I) levels were measured, as IGF-I has been implicated in the pathogenesis of compensatory renal growth (CRG) and VEGF has been suggested to be a downstream mediator of IGF-I. Placebo-treated uninephrectomized mice displayed an early transient increase in kidney IGF-I concentration and an increase in glomerular volume and kidney weight. In VEGF-ab treated uninephrectomized animals, increased glomerular volume was abolished, while renal hypertrophy was partially blocked. Further, the renal effects of VEGF-ab administration were seen without affecting the renal IGF-I levels. In conclusion, these results demonstrate that compensatory glomerular growth following uninephrectomy is VEGF dependent.
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