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Am J Physiol Endocrinol Metab 295: E989, 2008; doi:10.1152/ajpendo.90633.2008
0193-1849/08 $8.00
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LETTERS TO THE EDITOR

Reply to Collazos

Philip Knapp and Shalender Bhasin

Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts

TO THE EDITOR: We agree with Dr. Collazos that the spectrum of HIV-associated weight loss has changed dramatically with the widespread use of combination antiretroviral therapy. The field has advanced substantially since our study was designed and conducted (1). The questions raised by Dr. Collazos are valid and interesting, but unfortunately our study does not have the statistical power to perform the subgroup analyses that he proposes. These questions could form the basis for an important additional study. Our group has also recently participated in a related study on testosterone supplementation in HIV-infected men with abdominal obesity and low testosterone, which demonstrated a decrease in fat mass and an increase in lean mass with testosterone supplementation in this group as well (2).

FOOTNOTES


Address for reprint requests and other correspondence: P. Knapp, Section of Endocrinology, Diabetes, and Nutrition, Boston Univ. School of Medicine and Boston Medical Center, 88 E. Newton St., Boston, MA 02118 (e-mail: philip.knapp{at}bmc.org)

REFERENCES

  1. Knapp PE, Storer TW, Herbst K, Singh AB, Dzekov C, Dzekov J, LaValley M, Zhang A, Ulloor J, Bhasin S. Effects of a supraphysiological dose of testosterone on physical function, fatigue, and mood in men with human immunodeficiency virus-associated weight loss. Am J Physiol Endocrinol Metab 294: E1135–E1143, 2008.[Abstract/Free Full Text]
  2. Bhasin S, Parker RA, Sattler F, Haubrich R, Alston B, Umbleja T, Shikuma CM; for the AIDS Clinical Trials Group Protocol A5097 Study Team. Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab 92: 1049–1057, 2007.[Abstract/Free Full Text]




This Article
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Right arrow Alert me when this article is cited
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Right arrow Similar articles in Web of Science
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PubMed
Right arrow Articles by Knapp, P.
Right arrow Articles by Bhasin, S.

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