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CORRIGENDA

Volume 289, October 2005

Volume 52, October 2005

Pages E703–E709: Hull RL, Watts MR, Kodama K, Shen Z, Utzschneider KM, Carr DB, Vidal J, and Kahn SE. "Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice." (http://ajpendo.physiology.org/cgi/content/full/289/4/E703).

In the printed version, on p. E706, the symbols for Fig. 3C were shown incorrectly. As shown here in the corrected figure (Fig. 1), the symbols should have appeared as open squares (, DBA2 nontransgenic mice), closed squares (, DBA2 hIAPP transgenic mice), open circles (, BL6 nontransgenic mice), and closed circles (, BL6 hIAPP transgenic mice).

View larger version (35K): [in this window] [in a new window]   Fig. 1. Mean islet area (A) and proportion of -cell area to islet area (B) in BL6 nontransgenic (open bars), BL6 hIAPP transgenic (gray bars), DBA2 nontransgenic (hatched bars) and DBA2 hIAPP transgenic mice (filled bars). Mean islet area was comparable between nontransgenic (NT) and hIAPP transgenic (T) mice of the same genotype but was significantly lower for both groups of BL6 mice compared with DBA2 nontransgenic and hIAPP transgenic mice (P < 0.05). The proportion of -cell area/islet area was similar between BL6 nontransgenic and hIAPP transgenic mice but was significantly lower in DBA2 hIAPP transgenic mice compared with their nontransgenic littermates (P < 0.05). Plasma glucose (C) and insulin levels (D) during an IVGTT in BL6 nontransgenic (), BL6 hIAPP transgenic (), DBA2 nontransgenic () and DBA2 hIAPP transgenic mice (). Plasma glucose levels were significantly higher in BL6 nontransgenic than in BL6 hIAPP transgenic mice for all time points (P < 0.05), whereas plasma glucose levels were similar between DBA2 nontransgenic and hIAPP transgenic mice. Plasma insulin levels were not different at any time point during the IVGTT between BL6 nontransgenic and BL6 hIAPP transgenic mice. In contrast, fasting plasma insulin was increased in DBA2 hIAPP transgenic mice (P = 0.05), whereas insulin secretion following iv glucose was reduced in DBA2 hIAPP transgenic compared with DBA2 nontransgenic mice.

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