|
|
Table 2.
Serum total and free testosterone, LH, FSH, SHBG, and IGF-I levels
|
|
Testosterone
Dose |
Baseline |
Week 16 |
Change from
Baseline |
P vs. Zero Change
|
|
| Testosterone (ng/dl) (overall ANOVA P = 0.0001)
|
| 25 mg |
593 ± 48 |
253 ± 66 |
 340 ± 85 |
0.0029
|
| 50 mg |
566 ± 78 |
306 ± 58 |
260 ± 64 |
0.0037
|
| 125 mg |
553 ± 53 |
570 ± 75 |
57 ± 75 |
0.7425
|
| 300 mg |
653 ± 50 |
1,345 ± 139 |
691 ± 143 |
0.0005
|
| 600 mg |
632 ± 63 |
2,370 ± 150 |
1,737 ± 156 |
0.0001
|
| Free testosterone (pg/ml)
(overall ANOVA P = 0.0001)
|
| 25 mg |
62 ± 6 |
29 ± 5 |
33 ± 8 |
0.0014
|
| 50 mg |
57 ± 6 |
32 ± 3 |
25 ± 5 |
0.0009
|
| 125 mg |
49 ± 5 |
52 ± 8 |
3 ± 7 |
0.8601
|
| 300 mg |
71 ± 7 |
138 ± 21 |
67 ± 18 |
0.0012
|
| 600 mg |
64 ± 5 |
275 ± 30 |
211 ± 31 |
0.0001
|
| LH (U/l) (overall ANOVA P = 0.8054)
|
| 25 mg |
3.5 ± 0.4 |
0.3 ± 0.1 |
3.2 ± 0.4 |
0.0001
|
| 50 mg |
3.8 ± 0.3 |
0.6 ± 0.3 |
3.0 ± 0.4 |
0.0008
|
| 125 mg |
3.4 ± 0.3 |
0.5 ± 0.1 |
2.8 ± 0.4 |
0.0001
|
| 300 mg |
3.7 ± 0.5 |
0.6 ± 0.1 |
3.5 ± 0.5 |
0.0002
|
| 600 mg |
3.3 ± 0.3 |
0.6 ± 0.4 |
2.9 ± 0.4 |
0.0001
|
| SHBG (nmol/l) (overall ANOVA
P = 0.0001)
|
| 25 mg |
29.1 ± 2.9 |
28.5 ± 3.6 |
0.6 ± 2.9 |
0.8497
|
| 50 mg |
24.4 ± 3.4 |
21.1 ± 3.2 |
3.3 ± 1.1 |
0.0202
|
| 125 mg |
33.1 ± 4.2 |
28.9 ± 3.8 |
4.2 ± 2.6 |
0.1410
|
| 300 mg |
31.4 ± 3.8 |
22.4 ± 3.9 |
9.1 ± 3.7 |
0.0348
|
| 600 mg |
40.1 ± 4.9 |
20.6 ± 3.2 |
19.5 ± 2.8 |
0.0001
|
| IGF-I (ng/ml) (overall ANOVA
P = 0.0001)
|
| 25 mg |
268 ± 26 |
261 ± 35 |
7 ± 19 |
0.7462
|
| 50 mg |
246 ± 14 |
225 ± 12 |
20 ± 10 |
0.0797
|
| 125 mg |
299 ± 24 |
282 ± 31 |
18 ± 17 |
0.3284
|
| 300 mg |
314 ± 24 |
388 ± 30 |
74 ± 28 |
0.0272
|
| 600 mg |
227 ± 20 |
304 ± 21 |
77 ± 13 |
0.0001 |
|
|
Values on each day represent the mean (±SE) of all available
values on that day. However, the change represents the difference
between paired values only. Treatment values represent the day
113 (week 16) values, obtained 1 wk after the previous
testosterone injection. We used week 16 rather than
week 20 values because week 20 values were not
always drawn exactly 1 wk after the previous injection. LH and FSH,
luteinizing and follicle-stimulating hormones, respectively; SHBG, sex
hormone-binding globulin; IGF-I, insulin-like growth factor I. To
convert total testosterone levels to nmol/l, multiply by 0.03467. To
convert free testosterone levels to pg/ml, multiply by 3.467.
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|
