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This Article Full Text Full Text (PDF) All Versions of this Article: 296/5/E1140    most recent 90788.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stevenson, E. J. Articles by Trenell, M. I. Search for Related Content PubMed PubMed Citation Articles by Stevenson, E. J. Articles by Trenell, M. I.

Dietary glycemic index influences lipid oxidation but not muscle or liver glycogen oxidation during exercise

¹Division of Sports Sciences, Northumbria University, Newcastle upon Tyne; ²Newcastle Magnetic Resonance Centre, and ⁴MRC Muscle Performance and Training Laboratory, Newcastle University, Newcastle upon Tyne, United Kingdom; and ³Institute of Obesity, Nutrition, and Exercise, University of Sydney, Sydney, Australia

Submitted 23 September 2008 ; accepted in final form 12 February 2009

The glycemic index (GI) of dietary carbohydrates influences glycogen storage in skeletal muscle and circulating nonesterified fatty acid (NEFA) concentrations. We hypothesized that diets differing only in GI would alter intramuscular lipid oxidation and glycogen usage in skeletal muscle and liver during subsequent exercise. Endurance-trained individuals (n = 9) cycled for 90 min at 70% O_2peak and then consumed either high- or low-GI meals over the following 12 h. The following day after an overnight fast, the 90-min cycle was repeated. ¹H and ¹³C magnetic resonance spectroscopy was used before and after exercise to assess intramuscular lipid and glycogen content of the vastus muscle group and liver. Blood and expired air samples were collected at 15-min intervals throughout exercise. NEFA availability was reduced during exercise in the high- compared with the low-GI trial (area under curve 44.5 ± 6.0 vs. 38.4 ± 7.30 mM/h, P < 0.05). Exercise elicited an 55% greater reduction in intramyocellular triglyceride (IMCL) in the high- vs. low-GI trial (1.6 ± 0.2 vs. 1.0 ± 0.3 mmol/kg wet wt, P < 0.05). There was no difference in the exercise-induced reduction of the glycogen pool in skeletal muscle (76 ± 8 vs. 68 ± 5 mM) or in liver (65 ± 8 vs. 71 ± 4 mM) between the low- and high-GI trials, respectively. High-GI recovery diets reduce NEFA availability and increase reliance on IMCL during moderate-intensity exercise. Skeletal muscle and liver glycogen storage or usage are not affected by the GI of an acute recovery diet.

glycemic index; intramuscular lipid; glycogen; magnetic resonance spectroscopy; exercise; skeletal muscle; liver