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This Article Full Text Full Text (PDF) All Versions of this Article: 296/4/E898    most recent 90796.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Paulino, G. Articles by Raybould, H. E. Search for Related Content PubMed PubMed Citation Articles by Paulino, G. Articles by Raybould, H. E.

Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats

¹Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, ²United States Department of Agriculture/Agricultural Research Service Western Human Nutrition Research Center, and ³Department of Nutrition, University of California, Davis, California

Submitted 26 September 2008 ; accepted in final form 30 January 2009

The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.

cholecystokinin; diet-induced obesity; ghrelin

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