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Am J Physiol Endocrinol Metab 296: E343-E350, 2009. First published December 2, 2008; doi:10.1152/ajpendo.90693.2008
0193-1849/09 $8.00
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Renin dynamics in adipose tissue: adipose tissue control of local renin concentrations

Jason D. Fowler,1 Stacy B. Krueth,1 David A. Bernlohr,2 and Stephen A. Katz1

1Department of Integrative Biology and Physiology, University of Minnesota Medical School; and 2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota

Submitted 13 August 2008 ; accepted in final form 28 November 2008

The renin-angiotensin system (RAS) has been implicated in a variety of adipose tissue functions, including tissue growth, differentiation, metabolism, and inflammation. Although expression of all components necessary for a locally derived adipose tissue RAS has been demonstrated within adipose tissue, independence of local adipose RAS component concentrations from corresponding plasma RAS fluctuations has not been addressed. To analyze this, we varied in vivo rat plasma concentrations of two RAS components, renin and angiotensinogen (AGT), to determine the influence of their plasma concentrations on adipose and cardiac tissue levels in both perfused (plasma removed) and nonperfused samples. Variation of plasma RAS components was accomplished by four treatment groups: normal, DOCA salt, bilateral nephrectomy, and losartan. Adipose and cardiac tissue AGT concentrations correlated positively with plasma values. Perfusion of adipose tissue decreased AGT concentrations by 11.1%, indicating that adipose tissue AGT was in equilibrium with plasma. Cardiac tissue renin levels positively correlated with plasma renin concentration for all treatments. In contrast, adipose tissue renin levels did not correlate with plasma renin, with the exception of extremely high plasma renin concentrations achieved in the losartan-treated group. These results suggest that adipose tissue may control its own local renin concentration independently of plasma renin as a potential mechanism for maintaining a functional local adipose RAS.

renin-angiotensin system; angiotensinogen; myocardium; rat; plasma


Address for reprint requests and other correspondence: S. A. Katz, Dept. of Integrative Biology and Physiology, 6-125 Jackson Hall, 321 Church St. S. E., Univ. of Minnesota Medical School, Minneapolis, MN 55455 (e-mail: katzx001{at}umn.edu)






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