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This Article Full Text Full Text (PDF) All Versions of this Article: 295/6/E1298    most recent 90493.2008v2 90493.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Hiriart, M. Articles by Aguilar-Bryan, L. Search for Related Content PubMed PubMed Citation Articles by Hiriart, M. Articles by Aguilar-Bryan, L.

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Channel regulation of glucose sensing in the pancreatic β-cell

¹Biophysics Department, Instituto de Fisiología de Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico; and ²Pacific Northwest Research Institute, Seattle, Washington

Submitted 5 June 2008 ; accepted in final form 9 October 2008

ABSTRACT

Mammalian β-cells are acutely and chronically regulated by sensing surrounding glucose levels that determine the rate at which insulin is secreted, to maintain euglycemia. Experimental research in vitro and in vivo has shown that, when these cells are exposed to adverse conditions like long periods of hypoglycemia or hyperglycemia, their capability to sense glucose is decreased. Understanding the normal physiology and identifying the main players along this route becomes paramount. In this review, we have taken on the task of looking at the role that ion channels play in the regulation of this process, delineating the different families, and describing the signaling that parallels the glucose sensing process that results in insulin release.

transient receptor potential; sodium current; calcium current; insulin secretion; insulin secretion coupling

This article has been cited by other articles:

				P. A. Halban The right stuff: {beta}-cell channels, cycles, and sensors Am J Physiol Endocrinol Metab, December 1, 2008; 295(6): E1277 - E1278. [Full Text] [PDF]