HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 295/5/E1117    most recent 90542.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Attig, L. Articles by Abdennebi-Najar, L. Search for Related Content PubMed PubMed Citation Articles by Attig, L. Articles by Abdennebi-Najar, L.

Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development

¹Universite Paris-Sud, Institut National de la Recherche Agronomique, Unité Mixte de Recherche (UMR) 1197, Neurobiologie de l'Olfaction et de la Prise Alimentaire, Jouy-en-Josas; ²Institut Polytechnique Lasalle-Beauvais, Beauvais, France; ³The Hebrew University of Jerusalem, Rehovot, Israel; ⁴Institut National de la Recherche Agronomique, UMR 703 Ecole Nationale Vétérinaire, Nantes, France; and ⁵Service de médecine infantile C, Hôpital d'enfants, Tunis, Tunisia

Submitted 25 June 2008 ; accepted in final form 3 September 2008

Low birth weight resulting from intrauterine growth retardation (IUGR) is a risk factor for further development of metabolic diseases. The pig appears to reproduce nearly all of the phenotypic pathological consequences of human IUGR and is likely to be more relevant than rodents in studies of neonatal development. In the present work, we characterized the model of low-birth-weight piglets with particular attention to the hypothalamic leptin-sensitive system, and we tested whether postnatal leptin supplementation can reverse the precocious signs of adverse metabolic programming. Our results demonstrated that 1) IUGR piglets present altered postnatal growth and increased adiposity; 2) IUGR piglets exhibit abnormal hypothalamic distribution of leptin receptors that may be linked to further disturbance in food-intake behavior; and 3) postnatal leptin administration can partially reverse the IUGR phenotype by correcting growth rate, body composition, and development of several organs involved in metabolic regulation. We conclude that IUGR may be characterized by altered leptin receptor distribution within the hypothalamic structures involved in metabolic regulation and that leptin supplementation can partially reverse the IUGR phenotype. These results open interesting therapeutic perspectives in physiopathology for the correction of defects observed in IUGR.

intrauterine growth retardation; metabolic programming; obesity; catch-up growth; adipose tissue development

This article has been cited by other articles:

				D. D Briana and A. Malamitsi-Puchner Intrauterine growth restriction and adult disease: the role of adipocytokines Eur. J. Endocrinol., March 1, 2009; 160(3): 337 - 347. [Abstract] [Full Text] [PDF]