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Am J Physiol Endocrinol Metab 295: E553-E558, 2008. First published April 22, 2008; doi:10.1152/ajpendo.90261.2008
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PERSPECTIVES

Frontiers: Skeletal muscle sodium pump regulation: a translocation paradigm

Boubacar Benziane and Alexander V. Chibalin

Department of Molecular Medicine and Surgery, Karolinska Institutet, Section of Integrative Physiology, Stockholm, Sweden

Submitted 29 February 2008 ; accepted in final form 16 April 2008

ABSTRACT

The skeletal muscle sodium pump plays a major role in the removal of K+ ions from the circulation postprandial, or after a physical activity bout, thereby preventing the development of hyperkalemia and fatigue. Insulin and muscle contractions stimulate Na+-K+-ATPase activity in skeletal muscle, at least partially via translocation of sodium pump units to the plasma membrane from intracellular stores. The molecular mechanism of this phenomenon is poorly understood. Due to the contradictory reports in the literature, the very existence of the translocation of Na+-K+-ATPase to the skeletal muscle cell surface is questionable. This review summarizes more than 30 years work on the skeletal muscle sodium pump translocation paradigm. Furthermore, the methodological caveats of major approaches to study the sodium pump translocation in skeletal muscle are discussed. An understanding of the molecular regulation of Na+-K+-ATPase in skeletal muscle will have important clinical implications for the understanding of the development of complications associated with the metabolic syndrome, such as cardiovascular diseases or increased muscle fatigue in diabetic patients.

Na+-K+-ATPase; translocation; insulin; contraction; membrane traffic; ouabain


Address for reprint requests and other correspondence: A. V. Chibalin, Ph.D., Section of Integrative Physiology, Deptartment of Molecular Medicine and Surgery, Integrative Physiology, von Eulers vag 4, 4 tr, Karolinska Institutet 171 77, Stockholm Sweden (e-mail: Alexander.Chibalin{at}ki.se)




This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Clausen
Regulatory role of translocation of Na+-K+ pumps in skeletal muscle: hypothesis or reality?
Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E727 - E728.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. V. Chibalin and B. Benziane
Reply to Clausen letter
Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E729 - E729.
[Full Text] [PDF]


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