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This Article Full Text Full Text (PDF) All Versions of this Article: 295/2/E491    most recent 90481.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Lam, C. K. L. Articles by Lam, T. K. T. PubMed PubMed Citation Articles by Lam, C. K. L. Articles by Lam, T. K. T.

Central lactate metabolism regulates food intake

¹Department of Physiology and ²Department of Medicine, University of Toronto and ³Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

Submitted 30 May 2008 ; accepted in final form 17 June 2008

The central nervous system regulates food intake (FI) and body weight (BW), but the associated mechanisms remain to be elucidated. Here we report that central injections of lactate reduced FI and BW in rodents. Inhibition of central lactate metabolism to pyruvate with the lactate dehydrogenase inhibitor oxamate abolished the central effects of lactate on FI and BW. Conversely, central injections of pyruvate recapitulated the effects of lactate. Finally, inhibition of central lactate metabolism prevented the ability of circulating lactate to lower FI and BW. Together, the data indicate that activation of central lactate metabolism lowers FI and BW.

central nervous system; obesity; diabetes