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This Article Full Text Full Text (PDF) All Versions of this Article: 294/3/E576    most recent 00725.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Sverrisdóttir, Y. B. Articles by Stener-Victorin, E. Search for Related Content PubMed PubMed Citation Articles by Sverrisdóttir, Y. B. Articles by Stener-Victorin, E.

Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth?

¹Institute of Neuroscience and Physiology, Department of Physiology, and ²Department of Obstetrics and Gynecology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Submitted 19 November 2007 ; accepted in final form 3 January 2008

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disturbance among women of reproductive age and is proposed to be linked with size at birth and increased prevalence of cardiovascular disease. A disturbance in the sympathetic nervous system may contribute to the etiology of PCOS. This study evaluates sympathetic outflow in PCOS and its relation to size at birth. Directly recorded sympathetic nerve activity to the muscle vascular bed (MSNA) was obtained in 20 women with PCOS and in 18 matched controls. Ovarian ultrasonographic evaluation, biometric, hormonal, and biochemical parameters were measured, and birth data were collected. Women with PCOS had increased MSNA (30 ± 8 vs. 20 ± 7 burst frequency, P < 0.0005) compared with controls. MSNA was positively related to testosterone (r = 0.63, P < 0.005) and cholesterol (r = 0.55, P = 0.01) levels in PCOS, which, in turn, were not related to each other. Testosterone level was a stronger predictor of MSNA than cholesterol. Birth size did not differ between the study groups. This is the first study to directly address sympathetic nerve activity in women with PCOS and shows that PCOS is associated with high MSNA. Testosterone and cholesterol levels are identified as independent predictors of MSNA in PCOS, although testosterone has a stronger impact. The increased MSNA in PCOS may contribute to the increased cardiovascular risk and etiology of the condition. In this study, PCOS was not related to size at birth.

birth weight; testosterone; insulin resistance; metabolic syndrome; cardiovascular disease; autonomic nervous system

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