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THE WALTER B. CANNON PHYSIOLOGY IN PERSPECTIVE LECTURE, 2007

ATP-sensitive K⁺ channels and disease: from molecule to malady

Henry Wellcome Centre for Gene Function, University of Oxford, Oxford, United Kingdom

This essay is based on a lecture given to the American Physiological Society in honor of Walter B. Cannon, an advocate of homeostasis. It focuses on the role of the ATP-sensitive potassium K⁺ (K_ATP) channel in glucose homeostasis and, in particular, on its role in insulin secretion from pancreatic -cells. The -cell K_ATP channel comprises pore-forming Kir6.2 and regulatory SUR1 subunits, and mutations in either type of subunit can result in too little or too much insulin release. Here, I review the latest information on the relationship between K_ATP channel structure and function, and consider how mutations in the K_ATP channel genes lead to neonatal diabetes or congenital hyperinsulinism.

Kir6.2; SUR1; neonatal diabetes; hyperinsulinism

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				D. Benos Frances Ashcroft: 2007 Walter B. Cannon Physiology in Perspective Lecture Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E879 - E879. [Full Text] [PDF]