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This Article Full Text Full Text (PDF) All Versions of this Article: 293/1/E42    most recent 00610.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Jürimäe, J. Articles by Jürimäe, T. Search for Related Content PubMed PubMed Citation Articles by Jürimäe, J. Articles by Jürimäe, T.

Plasma adiponectin concentration in healthy pre- and postmenopausal women: relationship with body composition, bone mineral, and metabolic variables

Institute of Sport Pedagogy and Coaching Sciences, Center of Behavioral and Health Sciences, University of Tartu, Tartu, Estonia

Submitted 14 November 2006 ; accepted in final form 1 March 2007

The aim of the current investigation was to determine the possible relationships of fasting adiponectin level with body composition, bone mineral, insulin sensitivity, leptin, and cardiorespiratory fitness parameters in 153 women. Subjects were classified as premenopausal (n = 42; 40.8 ± 5.7 yr) if they had regular menstrual periods, early postmenopausal (n = 49; 56.7 ± 3.6 yr) if they had been postmenopausal for more than >1 yr but <7 yr (5.5 ± 1.3 yr), and postmenopausal (n = 62; 72.2 ± 4.5 yr) if they had been postmenopausal for >7 yr. All women studied had a body mass index (BMI) <30 kg/m². Adiponectin values were higher (P < 0.05) in middle-aged (12.0 ± 5.1 µg/ml) and older (15.3 ± 7.3 µg/ml) postmenopausal women compared with middle-aged premenopausal women (8.4 ± 3.2 µg/ml). Mean plasma adiponectin concentration in the total group of women (n = 153) was 12.2 ± 6.3 µg/ml and was positively related (P < 0.05) to age, indexes of overall obesity (BMI, body fat mass), and cardiorespiratory fitness (PWC) values. In addition, a negative association (P < 0.05) between adiponectin with central obesity (waist-to-hip and waist-to-thigh ratio), fat-free mass, bone mineral (bone mineral content, total and lumbar spine bone mineral density), and leptin and insulin resistance (insulin, fasting insulin resistance index) values was observed. However, multivariate regression analysis revealed that only age, fasting insulin resistance index, and leptin were independent predictors of adiponectin concentration. In conclusion, circulating adiponectin concentrations increase with age in normal-weight middle-aged and older women. It appears that adiponectin is independently related to age, leptin, and insulin resistance values in women across the age span and menstrual status.

adiponectin; leptin; age; menopausal status; insulin resistance