HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/6/E1590    most recent 00669.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Kim, S. P. Articles by Bergman, R. N. Search for Related Content PubMed PubMed Citation Articles by Kim, S. P. Articles by Bergman, R. N.

Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia

Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California

Submitted 7 December 2006 ; accepted in final form 29 January 2007

Obesity is strongly associated with hyperinsulinemia and insulin resistance, both primary risk factors for type 2 diabetes. It has been thought that increased fasting free fatty acids (FFA) may be responsible for the development of insulin resistance during obesity, causing an increase in plasma glucose levels, which would then signal for compensatory hyperinsulinemia. But when obesity is induced by fat feeding in the dog model, there is development of insulin resistance and a marked increase in fasting insulin despite constant fasting FFA and glucose. We examined the 24-h plasma profiles of FFA, glucose, and other hormones to observe any potential longitudinal postprandial or nocturnal alterations that could lead to both insulin resistance and compensatory hyperinsulinemia induced by a high-fat diet in eight normal dogs. We found that after 6 wk of a high-fat, hypercaloric diet, there was development of significant insulin resistance and hyperinsulinemia as well as accumulation of both subcutaneous and visceral fat without a change in either fasting glucose or postprandial glucose. Moreover, although there was no change in fasting FFA, there was a highly significant increase in the nocturnal levels of FFA that occurred as a result of fat feeding. Thus enhanced nocturnal FFA, but not glucose, may be responsible for development of insulin resistance and fasting hyperinsulinemia in the fat-fed dog model.

obesity; diurnal

This article has been cited by other articles:

				D.-E. Lee, S. Kehlenbrink, H. Lee, M. Hawkins, and J. S. Yudkin Getting the message across: mechanisms of physiological cross talk by adipose tissue Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1210 - E1229. [Abstract] [Full Text] [PDF]

				J. M. Richey, O. O. Woolcott, D. Stefanovski, L. N. Harrison, D. Zheng, M. Lottati, I. R. Hsu, S. P. Kim, M. Kabir, K. J. Catalano, et al. Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs Am J Physiol Endocrinol Metab, June 1, 2009; 296(6): E1311 - E1318. [Abstract] [Full Text] [PDF]

				D. Zheng, V. Ionut, V. Mooradian, D. Stefanovski, and R. N. Bergman Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver Diabetes, February 1, 2009; 58(2): 352 - 359. [Abstract] [Full Text] [PDF]

				H. E. Bates, A. Sirek, M. A. Kiraly, J. T. Y. Yue, M. C. Riddell, S. G. Matthews, and M. Vranic Adaptation to intermittent stress promotes maintenance of {beta}-cell compensation: comparison with food restriction Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E947 - E958. [Abstract] [Full Text] [PDF]

				F. Respondek, K. S. Swanson, K. R. Belsito, B. M. Vester, A. Wagner, L. Istasse, and M. Diez Short-Chain Fructooligosaccharides Influence Insulin Sensitivity and Gene Expression of Fat Tissue in Obese Dogs J. Nutr., September 1, 2008; 138(9): 1712 - 1718. [Abstract] [Full Text] [PDF]

				R. C. Boston and P. J. Moate NEFA minimal model parameters estimated from the oral glucose tolerance test and the meal tolerance test Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R395 - R403. [Abstract] [Full Text] [PDF]

				I. R Hsu, S. P Kim, M. Kabir, and R. N Bergman Metabolic syndrome, hyperinsulinemia, and cancer Am. J. Clinical Nutrition, September 1, 2007; 86(3): 867S - 871S. [Abstract] [Full Text] [PDF]