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This Article Full Text Full Text (PDF) All Versions of this Article: 292/5/E1441    most recent 00347.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kinzig, K. P. Articles by Guarda, A. S. Search for Related Content PubMed PubMed Citation Articles by Kinzig, K. P. Articles by Guarda, A. S.

Insulin, glucose, and pancreatic polypeptide responses to a test meal in restricting type anorexia nervosa before and after weight restoration

¹Department of Psychological Sciences, Purdue University, West Lafayette, Indiana; and ²Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland

Submitted 14 July 2006 ; accepted in final form 15 January 2007

Prolonged malnutrition in individuals with anorexia nervosa (AN) has been associated with alterations in endocrine function that may play a sustaining role in the disorder. We hypothesized that abnormalities in endocrine responses to ingestion of a meal in AN are reversible and depend on weight restoration. We measured meal-induced endocrine responses in AN subjects at three time points during hospitalization: before refeeding (n = 13, mean BMI 16.7 kg/m²), after 2 wk of refeeding (mean BMI 18.0 kg/m²), and in the weight-restored state (mean BMI 20.3 kg/m²). Control subjects (n = 13, BMI 19–24.9 kg/m²) were tested once. Tests were 2.5-h sessions in which blood was drawn every 15 min before, during, and after a 650-kcal test breakfast. Relative to controls, peak levels of glucose were depressed and peak levels of insulin in response to ingestion of the test meal were delayed, with response patterns in the third trial most similar to controls. Pancreatic polypeptide (PP) levels were increased in AN relative to controls regardless of weight status. The delay in insulin release and elevated PP levels did not correct with short-term refeeding and may contribute to the high relapse rates and maintenance of AN.

eating disorders; pancreatic function; refeeding