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Am J Physiol Endocrinol Metab 292: E865-E870, 2007; doi:10.1152/ajpendo.00533.2006 Free Article
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Effect of intermittent high-intensity compared with continuous moderate exercise on glucose production and utilization in individuals with type 1 diabetes

K. J. Guelfi,1 N. Ratnam,2,3 G. A. Smythe,4 T. W. Jones,2,3 and P. A. Fournier1

1School of Human Movement and Exercise Science, University of Western Australia, Crawley; 2Department of Endocrinology and Diabetes, Princess Margaret Hospital, Subiaco; 3Centre for Child Health Research, The University of Western Australia, Telethon Institute of Child Health Research, Perth, Western Australia; and 4Bioanalytical Mass Spectrometry Facility, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

Submitted 29 September 2006 ; accepted in final form 10 November 2006

Previously, the decline in glycemia in individuals with type 1 diabetes has been shown to be less with intermittent high-intensity exercise (IHE) compared with continuous moderate-intensity exercise (MOD) despite the performance of a greater amount of total work. The purpose of the present study was to determine whether this lesser decline in glycemia can be attributed to a greater increment in endogenous glucose production (Ra) or attenuated glucose utilization (Rd). Nine individuals with type 1 diabetes were tested on two separate occasions, during which either a 30-min MOD or IHE protocol was performed under conditions of a euglycemic clamp in combination with the infusion of [6,6-2H]glucose. MOD consisted of continuous cycling at 40% VO2 peak, whereas IHE involved a combination of continuous exercise at 40% VO2 peak interspersed with additional 4-s maximal sprint efforts performed every 2 min to simulate the activity patterns of intermittent sports. During IHE, glucose Ra increased earlier and to a greater extent compared with MOD. Similarly, glucose Rd increased sooner during IHE, but the increase by the end of exercise was comparable with that elicited by MOD. During early recovery from IHE, Rd rapidly declined, whereas it remained elevated after MOD, a finding consistent with a lower glucose infusion rate during early recovery from IHE compared with MOD (P < 0.05). The results suggest that the lesser decline in glycemia with IHE may be attributed to a greater increment in Ra during exercise and attenuated Rd during exercise and early recovery.

glycemia; hypoglycemia; physical activity


Address for reprint requests and other correspondence: K. J. Guelfi, School of Human Movement and Exercise Science, Univ. of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009 (e-mail: kym.guelfi{at}uwa.edu.au)






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