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Am J Physiol Endocrinol Metab 292: E24-E31, 2007. First published July 25, 2006; doi:10.1152/ajpendo.00113.2006
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Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise

Lone Frydelund-Larsen, Thorbjorn Akerstrom, Søren Nielsen, Pernille Keller, Charlotte Keller, and Bente Klarlund Pedersen

Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark

Submitted 10 March 2006 ; accepted in final form 29 June 2006

Visfatin [pre-beta-cell colony-enhancing factor (PBEF)] is a novel adipokine that is produced by adipose tissue, skeletal muscle, and liver and has insulin-mimetic actions. Regular exercise enhances insulin sensitivity. In the present study, we therefore examined visfatin mRNA expression in abdominal subcutaneous adipose tissue and skeletal muscle biopsies obtained from healthy young men at time points 0, 3, 4.5, 6, 9, and 24 h in relation to either 3 h of ergometer cycle exercise at 60% of VO2 max or rest. Adipose tissue visfatin mRNA expression increased threefold at the time points 3, 4.5, and 6 h in response to exercise (n = 8) compared with preexercise samples and compared with the resting control group (n = 7, P = 0.001). Visfatin mRNA expression in skeletal muscle was not influenced by exercise. The exercise-induced increase in adipose tissue visfatin was, however, not accompanied by elevated levels of plasma visfatin. Recombinant human IL-6 infusion to mimic the exercise-induced IL-6 response (n = 6) had no effect on visfatin mRNA expression in adipose tissue compared with the effect of placebo infusion (n = 6). The finding that exercise enhances subcutaneous adipose tissue visfatin mRNA expression suggests that visfatin has a local metabolic role in the recovery period following exercise.

metabolism; pre-beta-cell colony-enhancing factor; adipokines; exercise; interleukin-6; messenger RNA


Address for reprint requests and other correspondence: B. K. Pedersen, Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark (e-mail: BKP{at}rh.dk)






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