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EDITORIAL FOCUS
ESSAYS ON APS CLASSIC PAPERS
1The Hospital for Sick Children, Toronto; 2Department of Physiology, University of Toronto, Toronto, Ontario, Canada
ABSTRACT
This essay examines the historical significance of two APS classic papers that are freely available on line:
Wall JS, Steele R, de Bodo RC, and Altszuler N. Effect of insulin on utilization and production of circulating glucose. Am J Physiol 189: 4350, 1957. (http://ajplegacy.physiology.org/cgi/reprint/189/1/43)
DeFronzo RA, Tobin JD, and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Endocrinol Metab Gastroinstest Physiol 6: E214E223, 1979. (http://ajpgi.physiology.org/cgi/reprint/237/3/G214)
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