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Am J Physiol Endocrinol Metab 291: E1141-E1143, 2006; doi:10.1152/classicessays.00043.2006
0193-1849/06 $8.00

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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Muscle, liver, and pancreas: Three Musketeers fighting to control glycemia

¹The Hospital for Sick Children, Toronto; ²Department of Physiology, University of Toronto, Toronto, Ontario, Canada

ABSTRACT

This essay examines the historical significance of two APS classic papers that are freely available on line:

Wall JS, Steele R, de Bodo RC, and Altszuler N. Effect of insulin on utilization and production of circulating glucose. Am J Physiol 189: 43–50, 1957. (http://ajplegacy.physiology.org/cgi/reprint/189/1/43)

DeFronzo RA, Tobin JD, and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Endocrinol Metab Gastroinstest Physiol 6: E214–E223, 1979. (http://ajpgi.physiology.org/cgi/reprint/237/3/G214)