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Am J Physiol Endocrinol Metab 291: E439-E440, 2006. First published April 25, 2006; doi:10.1152/ajpendo.00105.2006
0193-1849/06 $8.00
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INVITED REVIEW

Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult

Faramarz Ismail-Beigi, Patrick M. Catalano, and Richard W. Hanson

Departments of Medicine, Reproductive Biology, and Biochemistry, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, Ohio

Exposure of the fetus to the intrauterine milieu can have profound effects on the health of the offspring in adulthood. Results of a series of studies demonstrate the powerful influence of the mother's metabolic state on whether the emerging adult develops obesity and hyperinsulinemia. Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and prevented.


Address for reprint requests and other correspondence: F. Ismail-Beigi, Dept. of Medicine, Cleveland Diabetes Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 (email: fxi2{at}case.edu)




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Expression of energy balance regulatory genes in the developing ovine fetal hypothalamus at midgestation and the influence of hyperglycemia
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[Abstract] [Full Text] [PDF]


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