AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 290: E1227-E1236, 2006; doi:10.1152/ajpendo.00344.2005
0193-1849/06 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, H.
Right arrow Articles by LeRoith, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, H.
Right arrow Articles by LeRoith, D.

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice

Hyunsook Kim,1,3,* Patricia A. Pennisi,1,* Oksana Gavrilova,2 Stephanie Pack,2 William Jou,2 Jennifer Setser-Portas,1 Joyce East-Palmer,1 Yan Tang,4 Vincent C. Manganiello,4 and Derek LeRoith1

1Diabetes Branch and 2Mouse Metabolism Core Laboratory, National Institute of Diabetes, Digestive and Kidney Diseases; 3Beltsville Human Nutrition Center, Agricultural Research Service-United States Department of Agriculture, Beltsville; and 4Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

Submitted 29 July 2005 ; accepted in final form 2 January 2006

The antiobesity and antidiabetic effects of the beta3-adrenergic agonists were investigated on nonobese type 2 diabetic MKR mice after injection with a beta3-adrenergic agonist, CL-316243. An intact response to acute CL-316243 treatment was observed in MKR mice. Chronic intraperitoneal CL-316243 treatment of MKR mice reduced blood glucose and serum insulin levels. Hyperinsulinemic euglycemic clamps exhibited improvement of the whole body insulin sensitivity and glucose homeostasis concurrently with enhanced insulin action in liver and adipose tissue. Treating MKR mice with CL-316243 significantly lowered serum and hepatic lipid levels, in part due to increased whole body triglyceride clearance and fatty acid oxidation in adipocytes. A significant reduction in total body fat content and epididymal fat weight was observed along with enhanced metabolic rate in both wild-type and MKR mice after treatment. These data demonstrate that beta3-adrenergic activation improves the diabetic state of nonobese diabetic MKR mice by potentiation of free fatty acid oxidation by adipose tissue, suggesting a potential therapeutic role for beta3-adrenergic agonists in nonobese diabetic subjects.

insulin-like growth factor I receptor mutation; type 2 diabetes


Address for reprint requests and other correspondence: D. LeRoith, Division of Endocrinology, Diabetes, and Bone Diseases, Mt. Sinai School of Medicine, 1 Gustave Levy Place (1055), New York, NY 10029 (e-mail: derek.leroith{at}mssu.edu)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.