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This Article Full Text Full Text (PDF) All Versions of this Article: 290/2/E243    most recent 00118.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Zelena, D. Articles by Makara, G. B. Search for Related Content PubMed PubMed Citation Articles by Zelena, D. Articles by Makara, G. B.

Hypothalamic paraventricular nucleus, but not vasopressin, participates in chronic hyperactivity of the HPA axis in diabetic rats

¹Institute of Experimental Medicine, Hungarian Academy of Sciences; ²Laboratory of Neuromorphology, Semmelweis University Medical School, Budapest, Hungary; and ³Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, St. Petersburg, Russia

Submitted 17 March 2005 ; accepted in final form 1 September 2005

Diabetes mellitus (DM), as chronic stress activates the hypothalamo-pituitary-adrenocortical axis. We examined whether arginine vasopressin (AVP) and the hypothalamic paraventricular nucleus (PVN) participate in DM-induced chronic stress symptoms. AVP-deficient Brattleboro or PVN-lesioned Wistar rats were used with heterozygous or sham-operated controls. The rats were studied 2 wk after a single injection of streptozotocin. The appearance of DM (enhanced water consumption and blood glucose elevation) and the chronic stress-like somatic changes (body weight decrease, thymus involution, adrenal gland hypertrophy) were not influenced by the lack of AVP. By contrast, PVN lesion significantly attenuated DM-induced thymus involution and adrenal gland hypertrophy as well as the increase in water consumption. The corticotropin-releasing hormone mRNA in PVN was diminished by DM and elevated by the lack of AVP without interaction. DM elevated the proopiomelanocortin (POMC) mRNA in the anterior lobe of the pituitary. The lack of AVP had no effect, whereas lesioning the PVN significantly diminished the elevation. The elevated basal corticosterone plasma levels detectable in DM were influenced neither by the lack of AVP nor by lesioning the PVN. Thus the lack of AVP had no influence on DM-induced chronic stress symptoms, but lesioning the PVN attenuated part of them. However, the lack of elevation in POMC mRNA after PVN lesion, together with the maintained corticosterone elevation, suggests that direct adrenal gland activation occurs in untreated DM.

chronic stress; Brattleboro rats; corticosterone; proopiomelanocortin; corticotropin-releasing hormone; diabetes mellitus; hypothalamo-pituitary-adrenocortical axis

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				D. Zelena, A. Domokos, S. K. Jain, R. Jankord, and L. Filaretova The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress J. Endocrinol., August 1, 2009; 202(2): 263 - 278. [Abstract] [Full Text] [PDF]

				A. Domokos, Z. Mergl, I. Barna, G. B Makara, and D. Zelena Congenital vasopressin deficiency and acute and chronic opiate effects on hypothalamo-pituitary adrenal axis activity in Brattleboro rats J. Endocrinol., January 1, 2008; 196(1): 113 - 121. [Abstract] [Full Text] [PDF]