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This Article Full Text Full Text (PDF) All Versions of this Article: 289/6/E1030    most recent 00124.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Hansen, M. Articles by Lange, K. H. W. Search for Related Content PubMed PubMed Citation Articles by Hansen, M. Articles by Lange, K. H. W.

Effects of 2 wk of GH administration on 24-h indirect calorimetry in young, healthy, lean men

¹Institute of Sports Medicine, ²Team Denmark Test Center, Bispebjerg Hospital, Copenhagen; ³Medical Research Laboratories, Aarhus University Hospital, Aarhus; ⁴Medical and Science Development Projects, Novo Nordisk, Bagsværd; and ⁵Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

Submitted 18 March 2005 ; accepted in final form 20 July 2005

The present study was designed as a randomized, double-blind placebo (Plc)-controlled study to determine the effect of 2 wk of growth hormone administration (GH-adm.) on energy expenditure (EE) and substrate oxidation in healthy humans. Sixteen young healthy men were divided into two groups. The study consisted of two 24-h measurements (indirect calorimetry), separated by 2 wk of either Plc or GH injections (6 IU/day). At baseline, no significant differences were observed between the two groups in any of the measured anthropometric, hormonal, or metabolic parameters, neither did the parameters change over time in the Plc group. GH-adm. resulted in a 4.4% increase in 24-h EE (P < 0.05) and an increase in fat oxidation by 29% (P < 0.05). However, a decrease in the respiratory quotient was only observed in the postabsorptive phase after an overnight fast (0.84 ± 0.1 to 0.79 ± 0.1, P < 0.05). Furthermore, lean body mass (LBM) was increased by GH-adm. only [62.8 ± 2.5 kg (baseline) vs. 64.7 ± 2.4 kg (after), P < 0.001]. In conclusion, GH-adm. increases 24-h EE, which may be partly explained by increased LBM. Furthermore, GH-adm. stimulates fat combustion, especially in the postabsorptive state.

energy expenditure; fat oxidation; growth hormone; insulin-like growth factor I; metabolism

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