AJP - Endo Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 289: E1023-E1029, 2005. First published July 19, 2005; doi:10.1152/ajpendo.00193.2005
0193-1849/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
289/6/E1023    most recent
00193.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Civitarese, A. E.
Right arrow Articles by Schrauwen, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Civitarese, A. E.
Right arrow Articles by Schrauwen, P.

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes

Anthony E. Civitarese,1 Matthijs K. C. Hesselink,2 Aaron P. Russell,3 Eric Ravussin,1 and Patrick Schrauwen4

1Pennington Biomedical Research Center, Baton Rouge, Louisiana; Departments of 2Movement Sciences and 4Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, The Netherlands; and 3Romande Rehabilitation Clinic, SUVACare, Sion, Switzerland

Submitted 3 May 2005 ; accepted in final form 14 July 2005

Ingestion of carbohydrate during exercise may blunt the stimulation of fat oxidative pathways by raising plasma insulin and glucose concentrations and lowering plasma free fatty acid (FFA) levels, thereby causing a marked shift in substrate oxidation. We investigated the effects of a single 2-h bout of moderate-intensity exercise on the expression of key genes involved in fat and carbohydrate metabolism with or without glucose ingestion in seven healthy untrained men (22.7 ± 0.6 yr; body mass index: 23.8 ± 1.0 kg/m2; maximal O2 consumption: 3.85 ± 0.21 l/min). Plasma FFA concentration increased during exercise (P < 0.01) in the fasted state but remained unchanged after glucose ingestion, whereas fat oxidation (indirect calorimetry) was higher in the fasted state vs. glucose feeding (P < 0.05). Except for a significant decrease in the expression of pyruvate dehydrogenase kinase-4 (P < 0.05), glucose ingestion during exercise produced minimal effects on the expression of genes involved in carbohydrate utilization. However, glucose ingestion resulted in a decrease in the expression of genes involved in fatty acid transport and oxidation (CD36, carnitine palmitoyltransferase-1, uncoupling protein 3, and 5'-AMP-activated protein kinase-{alpha}2; P < 0.05). In conclusion, glucose ingestion during exercise decreases the expression of genes involved in lipid metabolism rather than increasing genes involved in carbohydrate metabolism.

skeletal muscle gene expression; exercise-diet interaction


Address for reprint requests and other correspondence: E. Ravussin, Dept. of Human Physiology, Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA 70808 (e-mail: RavussE{at}pbrc.edu)




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. De Bock, W. Derave, B. O. Eijnde, M. K. Hesselink, E. Koninckx, A. J. Rose, P. Schrauwen, A. Bonen, E. A. Richter, and P. Hespel
Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake
J Appl Physiol, April 1, 2008; 104(4): 1045 - 1055.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.