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Am J Physiol Endocrinol Metab 289: E363-E365, 2005; doi:10.1152/classicessays.00034.2005 Free Article
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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Estimation of dose-response curves and identification of peaks in hormone pulsations: classic marriages of statistics to science

Douglas Curran-Everett

Division of Biostatistics, National Jewish Medical and Research Center, and Departments of Preventive Medicine and Biometrics and of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado

ABSTRACT

This essay examines the historical significance of two APS classic papers that are freely available online: De Léan A, Munson PJ, and Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol Endocrinol Metab Gastrointest Physiol 235: E97–E102, 1978 (http://ajplegacy.physiology.org/cgi/reprint/235/2/E97). Merriam GR and Wachter KW.Algorithms for the study of episodic hormone secretion. Am J Physiol Endocrinol Metab 243: E310–E318, 1982 (http://ajplegacy.physiology.org/cgi/reprint/243/4/E310).


Address for reprint requests and other correspondence: D. Curran-Everett, Division of Biostatistics, M222, National Jewish Medical and Research Center, 1400 Jackson St., Denver, CO 80206 (e-mail: EverettD{at}njc.org)




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