HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Am J Physiol Endocrinol Metab 289: E363-E365, 2005; doi:10.1152/classicessays.00034.2005
0193-1849/05 $8.00

This Article Free upon publication Full Text Full Text (PDF) Corrigendum Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Curran-Everett, D. Search for Related Content PubMed PubMed Citation Articles by Curran-Everett, D.

EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Estimation of dose-response curves and identification of peaks in hormone pulsations: classic marriages of statistics to science

Division of Biostatistics, National Jewish Medical and Research Center, and Departments of Preventive Medicine and Biometrics and of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado

ABSTRACT

This essay examines the historical significance of two APS classic papers that are freely available online: De Léan A, Munson PJ, and Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol Endocrinol Metab Gastrointest Physiol 235: E97–E102, 1978 (http://ajplegacy.physiology.org/cgi/reprint/235/2/E97). Merriam GR and Wachter KW.Algorithms for the study of episodic hormone secretion. Am J Physiol Endocrinol Metab 243: E310–E318, 1982 (http://ajplegacy.physiology.org/cgi/reprint/243/4/E310).