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This Article Full Text Full Text (PDF) All Versions of this Article: 289/2/E322    most recent 00408.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Scuteri, A. Articles by Lakatta, E. G. Search for Related Content PubMed PubMed Citation Articles by Scuteri, A. Articles by Lakatta, E. G.

apoE4 allele and the natural history of cardiovascular risk factors

¹Laboratory of Cardiovascular Science, ³Clinical Research Branch, ⁴Laboratory of Clinical Investigation, and ⁵Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; ²Unità Operativa Geriatria, Istituto Nazionale Ricovero e Cura per Anziani Rome, Italy; and ⁶Loyola College in Maryland, Baltimore, Maryland

Submitted 8 September 2004 ; accepted in final form 10 March 2005

The aims of the present study were to compare the longitudinal changes in traditional cardiovascular (CV) risk factors (blood pressure, BMI, total and HDL-cholesterol, triglycerides, and blood glucose) in men with and without the apolipoprotein (apo)E4 allele. Three hundred six men from the Baltimore Longitudinal Study of Aging, ranging in age from 20 to 92 yr, were studied. Repeated measurements of CV risk factors were performed over a median follow-up time of 7 yr (maximum 14.3 yr) for men. Longitudinal changes in these CV risk factors were analyzed by linear mixed-effects models. The prevalence of the apoE4 allele was 25.5%. apoE4 was independently associated with accelerated changes over time in fasting plasma glucose (+9.5% vs. no change in those without apoE4 in the 6th age-decade over 10 yr). No significant effect of apoE4 on longitudinal changes in total or HDL-cholesterol, triglycerides, or blood pressures was observed. In conclusion, apoE4 influences fasting plasma glucose and its changes over time. This could explain, in part, the increased CV risk associated with the apoE4 genotype observed in men.

apolipoprotein E4; genetics of vascular disorders; population studies; longitudinal studies; risk factors; glucose

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