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This Article Full Text Full Text (PDF) All Versions of this Article: 289/2/E212    most recent 00603.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Tsai, L.-L. Articles by Tzeng, J.-E. Search for Related Content PubMed PubMed Citation Articles by Tsai, L.-L. Articles by Tzeng, J.-E.

Repeated light-dark shifts speed up body weight gain in male F344 rats

¹Department of Psychology, National Chung-Cheng University and Departments of ²Laboratory Medicine and ³Pathology, Buddhist Dalin Tzu Chi General Hospital, Chia-yi, Taiwan, Republic of China

Submitted 20 December 2004 ; accepted in final form 28 February 2005

This study is aimed at verifying the causal relationship of chronic circadian desynchronization and changes in body weight control. Eight male albino F344 rats aged between 12–15 wk were subjected to twice weekly 12-h shifts of the daily light-dark (LD) cycle for 13 wk (3 mo). Continuous circadian phase shifts consisting of intermittent phase delay and advance and reduced circadian amplitudes were consistently displayed in all five experimental rats implanted intraperitoneally with heart rate, body temperature, and activity transponders. The experimental rat maintained a greater body weight during LD shifts and even after 10 days of recovery than that of the age-matched control rat, which was maintained on a regular LD cycle. Body weight gain was greater in the first 2 mo of LD shifts in the experimental rat than in the control rat. Relative to the baseline, food intake and activity percentages were increased and reduced, respectively, for the experimental rats. Features of these results, such as increased body weight gain and food intake, and reduced activity, suggest a causal relationship of chronic circadian desynchronization and changes in body weight control in male albino F344 rats.

shift work; circadian rhythm; reentrainment; energy regulation

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