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This Article Full Text Full Text (PDF) All Versions of this Article: 288/5/E852    most recent 00407.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by D’Elia, M. Articles by Bernier, J. Search for Related Content PubMed PubMed Citation Articles by D’Elia, M. Articles by Bernier, J.

Corticosterone binding globulin regulation and thymus changes after thermal injury in mice

¹Institut National de la Recherche Scientifique-Institut Armand-Frappier, Pointe-Claire; and ²Centre des grands brûlés de Montréal, Centre Hospitalier de l’Université de Montreal, Université de Montréal, Montreal, Quebec, Canada

Submitted 31 August 2004 ; accepted in final form 9 December 2004

Thermal injury is extremely stressful, and data characterizing the systemic endocrine stress response to this injury are sparse. The objective of this study was to measure the effects of thermal injury on mice on corticosterone (Cort) levels in relation with corticosteroid-binding globulin (CBG) and thymus cell populations. The endocrine stress response was determined by measuring total Cort, free Cort, CBG binding capacity, liver CBG mRNA, and circulating CBG levels at 1, 2, 5, and 10 days postburn. Thymus cell populations were also analyzed. After thermal injury, a rapid increase of total Cort was observed in the first 48 h. This was associated with a decrease of hepatic CBG mRNA, protein levels, and binding capacity. Percentage of free Cort in the burn group peaked at day 2 postburn with a dramatic (+500%) increase. This correlated with a significant decrease of thymus cellularity (50% less). Phenotypic analyses showed that corticosensitive cells were significantly altered. After treatment (5 days), both endocrine and immune parameters returned to control levels. Our results demonstrate that, after a thermal injury, CBG is mainly responsible for Cort’s action on corticosensitive immune cells.

glucocorticoids; corticosteroid-binding globulin; burn injury; immune system

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