AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 286: E844-E851, 2004. First published January 21, 2004; doi:10.1152/ajpendo.00556.2003
0193-1849/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
286/5/E844    most recent
00556.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quadro, L.
Right arrow Articles by Blaner, W. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quadro, L.
Right arrow Articles by Blaner, W. S.

Transplacental delivery of retinoid: the role of retinol-binding protein and lipoprotein retinyl ester

Loredana Quadro,1,2 Leora Hamberger,1 Max E. Gottesman,1 Vittorio Colantuoni,2 Rajasekhar Ramakrishnan,3 and William S. Blaner4

1Institute of Cancer Research and Departments of 3Pediatrics and 4Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032; and 2Department of Biological and Environmental Sciences, University of Sannio, 82100 Benevento, Italy

Submitted 8 December 2003 ; accepted in final form 17 January 2004

Retinoids are required for normal embryonic development. Both embryonic retinoid deficiency and excess result in congenital malformations. There is little understanding of the physiology underlying retinoid transfer from the maternal circulation to the embryo. We now report studies that explore this process using retinol-binding protein-deficient (RBP–/–) mice and mice that express human RBP on the RBP–/– background. Our studies establish that dietary retinoid, bound to lipoproteins, can serve as an important source for meeting tissue retinoid requirements during embryogenesis. Indeed, retinyl ester concentrations in the circulations of pregnant RBP–/– mice are significantly elevated over those observed in wild-type mice, suggesting that lipoprotein retinyl esters may compensate for the absence of retinol-RBP during pregnancy. We also demonstrate, contrary to earlier proposals, that maternal RBP does not cross the placenta and cannot enter the fetal circulation. Overall, our data indicate that both retinol-RBP and retinyl esters bound to lipoproteins are able to provide sufficient retinoid to the embryo to allow for normal embryonic development.

retinol; chylomicron; vitamin A; embryogenesis; placenta


Address for reprint requests and other correspondence: W. S. Blaner, Columbia Univ., Dept. of Medicine, Hammer Health Sciences Bldg., Rm. 502, 701 West 168th St., New York, NY 10032 (E-mail: wsb2{at}columbia.edu).




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y.-K. Kim, L. Wassef, L. Hamberger, R. Piantedosi, K. Palczewski, W. S. Blaner, and L. Quadro
Retinyl Ester Formation by Lecithin:Retinol Acyltransferase Is a Key Regulator of Retinoid Homeostasis in Mouse Embryogenesis
J. Biol. Chem., February 29, 2008; 283(9): 5611 - 5621.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Sankaranarayanan, M. Suarez, D. Taren, D. Genaro-Wolf, B. Duncan, K. Shrestha, N. Shrestha, and F. J. Rosales
The Concentration of Free Holo-Retinol Binding Protein Is Higher in Vitamin A-Sufficient than in Deficient Nepalese Women in Late Pregnancy
J. Nutr., December 1, 2005; 135(12): 2817 - 2822.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
L. Quadro, W. S. Blaner, L. Hamberger, P. M. Novikoff, S. Vogel, R. Piantedosi, M. E. Gottesman, and V. Colantuoni
The role of extrahepatic retinol binding protein in the mobilization of retinoid stores
J. Lipid Res., November 1, 2004; 45(11): 1975 - 1982.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.