| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
protein expression in rat epitrochlearis and soleus muscle
1Laboratory of Exercise Physiology, Division of Health Promotion and Exercise, National Institute of Health and Nutrition, Shinjuku City, Tokyo 162-8636; and 2Department of Sports Sciences, School of Human Sciences, Waseda University, Tokorozawa City, Saitama, 359-1192, Japan
Submitted 5 February 2003 ; accepted in final form 29 September 2003
The purpose of this study was to elucidate the mechanisms underlying low-intensity exercise-induced peroxisome proliferator-activated receptor-
coactivator-1
(PGC-1) protein expression in rat skeletal muscles. Rats (5–6 wk old) swam without a load and ran on the treadmill at a speed of 13 m/min, respectively, in two 3-h sessions separated by 45 min of rest. PGC-1 content in epitrochlearis muscle (EPI) was increased by 75 and 95%, immediately and 6 h after swimming, respectively, with no increase in PGC-1 content in the soleus (SOL). After running, PGC-1 content in EPI was unchanged, whereas a 107% increase in PGC-1 content was observed in SOL 6 h after running. Furthermore, in EPI and SOL as well as other muscles (triceps, plantaris, red and white gastrocnemius), PGC-1 expression was enhanced concomitant with reduced glycogen postexercise, suggesting that expression of PGC-1 occurs in skeletal muscle recruited during exercise. PGC-1 content in EPI was increased after 18-h in vitro incubation with 0.5 mM 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 4 mM caffeine. However, AICAR incubation did not affect PGC-1 content in the SOL, whereas caffeine incubation increased it. These results suggest that exercise-induced PGC-1 expression in skeletal muscle may be mediated by at least two exercise-induced signaling factors: AMPK activation and Ca2+ elevation. The number of factors involved (both AMPK and Ca2+, or Ca2+ only) in exercise-induced PGC-1 expression may differ among muscles.
peroxisome proliferator-activated receptor- coactivator-1; adenosine 5'-monophosphate-activated protein kinase; calcium; 5-aminoimidazole-4-carboxamide ribonucleoside; caffeine; low-intensity exercise
This article has been cited by other articles:
|
|
 |
|
  R. C. Scarpulla Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function Physiol Rev, April 1, 2008; 88(2): 611 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Aizawa, M. Iemitsu, T. Otsuki, S. Maeda, T. Miyauchi, and N. Mesaki Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats J Appl Physiol, January 1, 2008; 104(1): 67 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. H. Mortensen, P. Plomgaard, C. P. Fischer, A. K. Hansen, H. Pilegaard, and B. K. Pedersen PGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family J Appl Physiol, November 1, 2007; 103(5): 1536 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hashimoto, R. Hussien, S. Oommen, K. Gohil, and G. A. Brooks Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis FASEB J, August 1, 2007; 21(10): 2602 - 2612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Wadley and G. K. McConell Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle J Appl Physiol, January 1, 2007; 102(1): 314 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suwa, T. Egashira, H. Nakano, H. Sasaki, and S. Kumagai Metformin increases the PGC-1{alpha} protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo J Appl Physiol, December 1, 2006; 101(6): 1685 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Matsakas, C. Bozzo, N. Cacciani, F. Caliaro, C. Reggiani, F. Mascarello, and M. Patruno Effect of swimming on myostatin expression in white and red gastrocnemius muscle and in cardiac muscle of rats Exp Physiol, November 1, 2006; 91(6): 983 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Wu, X. Huang, Y. Feng, C. Handschin, Y. Feng, P. S. Gullicksen, O. Bare, M. Labow, B. Spiegelman, and S. C. Stevenson Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1{alpha} transcription and mitochondrial biogenesis in muscle cells PNAS, September 26, 2006; 103(39): 14379 - 14384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lucia, F. Gomez-Gallego, I. Barroso, M. Rabadan, F. Bandres, A. F. San Juan, J. L. Chicharro, U. Ekelund, S. Brage, C. P. Earnest, et al. PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men J Appl Physiol, July 1, 2005; 99(1): 344 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Bogacka, H. Xie, G. A. Bray, and S. R. Smith Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo Diabetes, May 1, 2005; 54(5): 1392 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Akimoto, T. J. Ribar, R. S. Williams, and Z. Yan Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1311 - C1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Watt, R J Southgate, A G Holmes, and M A Febbraio Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) {alpha} and {delta} and PPAR coactivator 1{alpha} in human skeletal muscle, but not lipid regulatory genes J. Mol. Endocrinol., October 1, 2004; 33(2): 533 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Akimoto, B. S. Sorg, and Z. Yan Real-time imaging of peroxisome proliferator-activated receptor-{gamma} coactivator-1{alpha} promoter activity in skeletal muscles of living mice Am J Physiol Cell Physiol, September 1, 2004; 287(3): C790 - C796. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
