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Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

¹Unité de Recherches sur les Obésités, U586, Institut National de la Santé et de la Recherche Médicale, Institut Louis Bugnard, Centre Hospitalier Universitaire, and ²Laboratoire de Statistiques et Probabilités, Université Paul Sabatier, 31403 Toulouse, France

Submitted 8 April 2003 ; accepted in final form 30 June 2003

The aim of this study was to investigate whether endurance training improves lipid mobilization and oxidation in overweight subjects. Eleven young men (25.6 ± 1.4 yr and body mass index 27.7 ± 0.2) performed a 4-mo training program consisting of practicing aerobic exercise 5 days/wk. Before and after the training period, lipid oxidation was explored during a 60-min exercise at 50% of peak O₂ consumption by use of indirect calorimetry. Lipid mobilization and antilipolytic ₂-adrenoceptor effect were also studied using the microdialysis method in abdominal subcutaneous adipose tissue (SCAT). After training, plasma nonesterified fatty acid (NEFA) levels, at rest and during exercise, were significantly lower than before (P < 0.001). Lipolysis in SCAT was significantly higher after than before training. An antilipolytic ₂-adrenoceptor effect in SCAT was underlined during exercise before training and disappeared after. The respiratory exchange ratio was lower after training, i.e., the percentage of lipid oxidation was higher only at rest. The amount of lipid oxidized was higher after training, at rest, and during exercise. Although exercise power was higher after training, the relative intensity was equivalent, as suggested by a similar increase in plasma catecholamine concentrations before and after training. In conclusion, 4-mo training in overweight men improved lipid mobilization through a decrease of antilipolytic ₂-adrenoceptor effect in SCAT and lipid oxidation during moderate exercise. Training induced a decrease of blood NEFA, predicting better prevention of obesity.

subcutaneous adipose tissue; microdialysis; catecholamines; ₂-adrenoceptor; exercise; lipid oxidation

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