AJP - Endo AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 285: E1089-E1094, 2003. First published June 24, 2003; doi:10.1152/ajpendo.00195.2003
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/5/E1089    most recent
00195.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (30)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Louis, M.
Right arrow Articles by Rennie, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Louis, M.
Right arrow Articles by Rennie, M. J.

No effect of creatine supplementation on human myofibrillar and sarcoplasmic protein synthesis after resistance exercise

Magali Louis,1 Jacques R. Poortmans,2 Marc Francaux,1 Jacques Berré,2 Nathalie Boisseau,3 Eric Brassine,2 Daniel J. R. Cuthbertson,4 Kenneth Smith,4 John A. Babraj,4 Tom Waddell,4 and Michael J. Rennie4

1Université Catholique de Louvain, 1348 Louvain, and 2Université Libre de Bruxelles, 1200 Brussels, Belgium; 3Université de Poitiers, 86034 Poitiers, France; and 4University of Dundee, Dundee DD1 4HN, Scotland

Submitted 29 April 2003 ; accepted in final form 19 June 2003

Muscle hypertrophy during resistance training is reportedly increased by creatine supplementation. Having previously failed to find an anabolic effect on muscle protein turnover at rest, either fed or fasted, we have now examined the possibility of a stimulatory effect of creatine in conjunction with acute resistance exercise. Seven healthy men (body mass index, 23 ± 2 kg/m2, 21 ± 1 yr, means ± SE) performed 20 x 10 repetitions of leg extension-flexion at 75% one-repetition maximum in one leg, on two occasions, 4 wk apart, before and after ingesting 21 g/day creatine for 5 days. The subjects ate ~21 g maltodextrin + 6 g protein/h for 3 h postexercise. We measured incorporation of [1-13C]leucine into quadriceps muscle proteins in the rested and exercised legs. Leg protein breakdown (as dilution of [2H5]phenylalanine) was also assessed in the exercised and rested leg postexercise. Creatine supplementation increased muscle total creatine by ~21% (P < 0.01). Exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by two- to threefold (P < 0.05), and leg phenylalanine balance became more positive, but creatine was without any anabolic effect.

skeletal muscle; protein turnover


Address for reprint requests and other correspondence: M. J. Rennie, University of Nottingham, Graduate Medical School, City Hospital, Uttoxeter Rd, Derby DE22 3NE, UK (E-mail: michael.rennie{at}nottingham.ac.uk).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
V. Kumar, P. Atherton, K. Smith, and M. J. Rennie
Human muscle protein synthesis and breakdown during and after exercise
J Appl Physiol, June 1, 2009; 106(6): 2026 - 2039.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. R. Moore, J. E. Tang, N. A. Burd, T. Rerecich, M. A. Tarnopolsky, and S. M. Phillips
Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise
J. Physiol., February 15, 2009; 587(4): 897 - 904.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Deldicque, P. Atherton, R. Patel, D. Theisen, H. Nielens, M. J. Rennie, and M. Francaux
Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle
J Appl Physiol, February 1, 2008; 104(2): 371 - 378.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Haus, J. A. Carrithers, S. W. Trappe, and T. A. Trappe
Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle
J Appl Physiol, December 1, 2007; 103(6): 2068 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. Deldicque, D. Theisen, L. Bertrand, P. Hespel, L. Hue, and M. Francaux
Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1263 - C1271.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Olsen, P. Aagaard, F. Kadi, G. Tufekovic, J. Verney, J. L. Olesen, C. Suetta, and M. Kjaer
Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training
J. Physiol., June 1, 2006; 573(2): 525 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. J. Cuthbertson, J. Babraj, K. Smith, E. Wilkes, M. J. Fedele, K. Esser, and M. Rennie
Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise
Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E731 - E738.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. L Kim, R. S Staron, and S. M Phillips
Fasted-state skeletal muscle protein synthesis after resistance exercise is altered with training
J. Physiol., October 1, 2005; 568(1): 283 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. R. Moore, S. M. Phillips, J. A. Babraj, K. Smith, and M. J. Rennie
Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions
Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1153 - E1159.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. M. Murphy, D. G. Stephenson, and G. D. Lamb
Effect of creatine on contractile force and sensitivity in mechanically skinned single fibers from rat skeletal muscle
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1589 - C1595.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. Paddon-Jones, E. Borsheim, and R. R. Wolfe
Potential Ergogenic Effects of Arginine and Creatine Supplementation
J. Nutr., October 1, 2004; 134(10): 2888S - 2894S.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.