HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (17) Citing Articles via Google Scholar Google Scholar Articles by Febbraio, M. A. Articles by Pedersen, B. K. Search for Related Content PubMed PubMed Citation Articles by Febbraio, M. A. Articles by Pedersen, B. K.

Hepatosplanchnic clearance of interleukin-6 in humans during exercise

¹Copenhagen Muscle Research Center and Departments of ²Hepatology, ³Infectious Diseases and ⁴Anesthesia, Rigshospitalet, and ⁵The August Krogh Institute, The University of Copenhagen, DK 2200 Copenhagen, Denmark; and ⁶Skeletal Muscle Research Laboratory, The School of Medical Sciences, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia

Submitted 27 March 2003 ; accepted in final form 25 April 2003

The cytokine interleukin (IL)-6 can increase markedly in the circulation during exercise, but whether the liver is a source of this increase is unknown. The aim of this study was to measure IL-6 flux across the hepatosplanchnic tissues in humans. To elevate systemic concentrations of IL-6, six healthy male subjects performed 120 min of semirecumbent cycling, and blood samples were simultaneously obtained from a brachial artery and the hepatic vein before and during exercise for the analysis of IL-6. Hepatosplanchnic blood flow (HBF) was measured using the indocyanine green infusion technique. Net hepatosplanchnic IL-6 balance was calculated from these measures. HBF was 1.3 ± 0.1 l/min at rest and was not reduced throughout exercise, averaging 1.1 ± 0.2 l/min. Arterial plasma IL-6 markedly increased (P < 0.05) from 1.8 ± 0.6 ng/l at rest to 14.3 ± 3.2 ng/l after 120 min of exercise. The hepatosplanchnic viscera did not contribute to this increase, since there was a net hepatosplanchnic IL-6 uptake (0.8 ± 0.3 vs. 5.5 ± 1.9 ng/min, rest vs. 120 min; P < 0.05). These data demonstrate that the hepatosplanchnic viscera remove IL-6 from the circulation in humans. This removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6.

liver; cytokine; metabolism; skeletal muscle contraction; blood flow

This article has been cited by other articles:

				H. B. Nielsen, M. A. Febbraio, P. Ott, P. Krustrup, and N. H. Secher Hepatic lactate uptake versus leg lactate output during exercise in humans J Appl Physiol, October 1, 2007; 103(4): 1227 - 1233. [Abstract] [Full Text] [PDF]

				B. W. Timmons, M. J. Hamadeh, M. C. Devries, and M. A. Tarnopolsky Influence of gender, menstrual phase, and oral contraceptive use on immunological changes in response to prolonged cycling J Appl Physiol, September 1, 2005; 99(3): 979 - 985. [Abstract] [Full Text] [PDF]

				L. Rosendal, K. Sogaard, M. Kjaer, G. Sjogaard, H. Langberg, and J. Kristiansen Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise J Appl Physiol, February 1, 2005; 98(2): 477 - 481. [Abstract] [Full Text] [PDF]

				A. G. Holmes, M. J. Watt, and M. A. Febbraio Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humans J Appl Physiol, August 1, 2004; 97(2): 689 - 696. [Abstract] [Full Text] [PDF]

				J. M. Dodd-o, L. E. Welsh, J. D. Salazar, P. L. Walinsky, E. A. Peck, J. G. Shake, D. J. Caparrelli, R. C. Ziegelstein, J. L. Zweier, W. A. Baumgartner, et al. Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H927 - H936. [Abstract] [Full Text] [PDF]