AJP - Endo AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 285: E82-E87, 2003. First published March 4, 2003; doi:10.1152/ajpendo.00275.2002
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/1/E82    most recent
00275.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (32)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McMahon, C. D.
Right arrow Articles by Bass, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McMahon, C. D.
Right arrow Articles by Bass, J. J.

Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension

Christopher D. McMahon,1 Ljiljana Popovic,1,2 Jenny M. Oldham,1 Ferenc Jeanplong,1 Heather K. Smith,3 Ravi Kambadur,1 Mridula Sharma,1 Linda Maxwell,2 and James J. Bass1

1Functional Muscle Genomics, AgResearch Limited, Ruakura Agricultural Centre, Hamilton; and Departments of 3Sport and Exercise Science and 2Pathology, University of Auckland, Auckland, New Zealand

Submitted 24 June 2002 ; accepted in final form 10 February 2003

Myostatin inhibits myogenesis. Therefore, we sought to determine if mice lacking the myostatin gene [Mstn(-/-)] would lose less muscle mass than wild-type mice during 7 days of hindlimb suspension (HS). Male Mstn(-/-) and wild-type (C57) mice were subjected to HS or served as ground-based controls (n = 6/group). Wild-type mice lost 8% of body mass and ~13% of wet mass from biceps femoris, quadriceps femoris, and soleus, whereas the mass of extensor digitorum longus (EDL) was unchanged after HS. Unexpectedly, Mstn(-/-) mice lost more body (13%, P < 0.05) and quadriceps femoris (17%, P < 0.05) mass than wild-type mice and lost 33% of EDL mass (P < 0.01) after HS. Protein expression of myostatin in biceps femoris and quadriceps femoris was not altered, whereas expression of MyoD, Myf-5, and myogenin increased in wild-type mice and tended to decrease in muscles of Mstn(-/-) mice. These data suggest that HS induced myogenesis in wild-type mice to counter atrophy, whereas myogenesis was not induced in Mstn(-/-) mice, thereby resulting in a greater loss of muscle mass.

muscle atrophy; muscle unloading; myostatin knockout


Address for reprint requests and other correspondence: C. D. McMahon, AgResearch Ltd., Ruakura Agricultural Centre, Private Bag 3123, Hamilton, New Zealand (E-mail: chris.mcmahon{at}agresearch.co.nz).




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
W. Guo, J. Flanagan, R. Jasuja, J. Kirkland, L. Jiang, and S. Bhasin
The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/{beta}-Catenin Signaling Pathways
J. Biol. Chem., April 4, 2008; 283(14): 9136 - 9145.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Mendias, J. E. Marcin, D. R. Calerdon, and J. A. Faulkner
Contractile properties of EDL and soleus muscles of myostatin-deficient mice
J Appl Physiol, September 1, 2006; 101(3): 898 - 905.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Y. -W. Chen, K. Nagaraju, M. Bakay, O. McIntyre, R. Rawat, R. Shi, and E. P. Hoffman
Early onset of inflammation and later involvement of TGF{beta} in Duchenne muscular dystrophy
Neurology, September 27, 2005; 65(6): 826 - 834.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. T. Iwaniec, T. J. Wronski, D. Amblard, Y. Nishimura, M. C. H. van der Meulen, C. E. Wade, M. A. Bourgeois, C. D. Damsky, and R. K. Globus
Effects of disrupted {beta}1-integrin function on the skeletal response to short-term hindlimb unloading in mice
J Appl Physiol, February 1, 2005; 98(2): 690 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. W. Jackman and S. C. Kandarian
The molecular basis of skeletal muscle atrophy
Am J Physiol Cell Physiol, October 1, 2004; 287(4): C834 - C843.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Peters, I. A Barash, M. Burdi, P. S Yuan, L. Mathew, J. Friden, and R. L Lieber
Asynchronous functional, cellular and transcriptional changes after a bout of eccentric exercise in the rat
J. Physiol., December 15, 2003; 553(3): 947 - 957.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. Wackerhage
Recovering from eccentric exercise: get weak to become strong
J. Physiol., December 15, 2003; 553(3): 681 - 681.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.