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Am J Physiol Endocrinol Metab 285: E31-E39, 2003. First published March 4, 2003; doi:10.1152/ajpendo.00552.2002
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Sexually dimorphic effects of maternal alcohol intake and adrenalectomy on left ventricular hypertrophy in rat offspring

Jennifer Slone Wilcoxon,1 Jeff Schwartz,2 Fraser Aird,1 and Eva E. Redei1

1Department of Psychiatry and Behavioral Sciences, Northwestern University Medical School, The Asher Center Chicago, Illinois 60611; and 2Department of Physiology, University of Adelaide, Adelaide, Australia 5005

Submitted 18 December 2002 ; accepted in final form 27 February 2003

In humans, low birth weight and increased placental weight can be associated with cardiovascular disease in adulthood. Low birth weight and increased placental size are known to occur after fetal alcohol exposure or prenatal glucocorticoid administration. Thus the effects of removing the alcohol-induced increase in maternal corticosterone by maternal adrenalectomy on predictors of cardiovascular disease in adulthood were examined in rats. Alcohol exposure of dams during the last 2 wk of gestation resulted in significantly decreased fetal weight and increased placental weight on gestational day 21. Adult female, but not male, offspring of alcohol-consuming mothers exhibited left ventricular hypertrophy. Placental 11{beta}-hydroxysteroid dehydrogenase-2 (11{beta}-HSD-2) mRNA levels, measured by Northern blot, were decreased in females but not males. Adrenalectomy of alcohol-consuming dams reversed the increase in placental weight and the decrease in female placental 11{beta}-HSD-2 expression and eliminated the left ventricular hypertrophy of adult female offspring. These data suggest that alcohol-induced changes in placental 11{beta}-HSD-2 mRNA levels and left ventricular weight are coupled in female offspring only and depend on maternal adrenal status.

corticosterone; 11{beta}-hydroxysteroid dehydrogenase-2; fetal alcohol exposure; birth weight; placental weight; adrenalectomized


Address for reprint requests and other correspondence: J. S. Wilcoxon, 303 E. Chicago Ave., Ward 9-190, Chicago, IL 60611 (E-mail: j-slone{at}northwestern.edu).




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 Am. J. Physiol. Endocrinol. Metab.Home page
J. Slone Wilcoxon and E. E. Redei
Prenatal programming of adult thyroid function by alcohol and thyroid hormones
Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E318 - E326.
[Abstract] [Full Text] [PDF]


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