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Am J Physiol Endocrinol Metab 284: E1112-E1118, 2003; doi:10.1152/ajpendo.00524.2002
0193-1849/03 $5.00
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Vol. 284, Issue 6, E1112-E1118, June 2003

Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk

Karen L. Herbst1, John K. Amory1, John D. Brunzell1, Howard A. Chansky2, and William J. Bremner1

1 Department of Medicine, and 2 Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98195

Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL2 and HDL3. It also might increase the number of small, dense, low-density lipoprotein cholesterol (LDL-C) particles in hypogonadal men. The decrease in HDL-C and in LDL-C size is potentially mediated by hepatic lipase activity, which hydrolyzes lipoprotein phospholipids and triacylglycerol. To determine how HDL-C and LDL-C particles are affected by testosterone administration to eugonadal men, testosterone was administered as a supraphysiological dose (600 mg/wk) for 3 wk to elderly, obese, eugonadal men before elective hip or knee surgery, and lipids were measured by routine methods and by density gradient ultracentrifugation. Hepatic lipase activity increased >60% above baseline levels, and HDL-C, HDL2, and HDL3 significantly declined in 3 wk. In addition, the LDL-C peak particle density and the amount of LDL-C significantly increased. Testosterone is therefore a potent stimulator of hepatic lipase activity, decreasing HDL-C, HDL2, and HDL3 as well as increasing LDL particle density changes, all associated with increased cardiovascular risk.

androgen; lipoprotein particle density


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