| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Diabetes Unit, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, 20892; and 2 Division of Biostatistics, Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Maryland 20850
Insulin resistance may link disorders of
metabolic homeostasis such as diabetes and obesity with disorders of
hemodynamic homeostasis such as hypertension. Thus it is of interest to
validate simple methods for quantifying insulin sensitivity in
hypertensive patients. The quantitative insulin-sensitivity check index
(QUICKI) is a novel mathematical transformation of fasting blood
glucose and insulin levels. In obese and diabetic subjects, QUICKI has a significantly better linear correlation with glucose clamp
determinations of insulin sensitivity than minimal-model estimates. To
determine whether QUICKI is also useful in hypertensive subjects, we
performed glucose clamps and frequently sampled intravenous glucose
tolerance tests (FSIVGTT) on 27 hypertensive subjects taken off
antihypertensive medication. Indexes of insulin sensitivity derived
from glucose clamp studies (SIClamp) were compared with
QUICKI, minimal-model analysis of FSIVGTTs (SIMM), and
homeostasis model assessment (HOMA). The correlation between QUICKI and
SIClamp (r = 0.84) was significantly better
than that between SIMM and SIClamp
(r = 0.65; P < 0.028). The correlation
between QUICKI and SIClamp was comparable to that between
1/HOMA and SIClamp (r = 0.82). When studies
were repeated in 14 subjects who had resumed antihypertensive medications, the percent changes in SIClamp for each of
these patients were significantly correlated with percent changes
in QUICKI (r = 0.61) and HOMA (r = 
0.54) but not SIMM (r = 0.18). We
conclude that QUICKI is a simple, robust index of insulin sensitivity that is useful for evaluating and following the insulin resistance of
hypertensive subjects in both research studies and clinical practice.
insulin resistance; diabetes; glucose clamp
This article has been cited by other articles:
|
|
 |
|
  P. Singal, R. Muniyappa, R. Chisholm, G. Hall, H. Chen, M. J. Quon, and K. J. Mather Simple modeling allows prediction of steady-state glucose disposal rate from early data in hyperinsulinemic glucose clamps Am J Physiol Endocrinol Metab, February 1, 2010; 298(2): E229 - E236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Muniyappa, H. Chen, R. H. Muzumdar, F. H. Einstein, X. Yan, L. Q. Yue, N. Barzilai, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E1023 - E1029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Muniyappa, G. Hall, T. L Kolodziej, R. J Karne, S. K Crandon, and M. J Quon Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1685 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee, R. Muniyappa, X. Yan, H. Chen, L. Q. Yue, E.-G. Hong, J. K. Kim, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E261 - E270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Muniyappa, S. Lee, H. Chen, and M. J. Quon Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E15 - E26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Schmiedel, M. L. Schroeter, and J. N. Harvey Microalbuminuria in Type 2 diabetes indicates impaired microvascular vasomotion and perfusion Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3424 - H3431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gilliam-Davis, V. S. Payne, S. O. Kasper, E. N. Tommasi, M. E. Robbins, and D. I. Diz Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1327 - H1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Potenza, F. L. Marasciulo, D. M. Chieppa, G. S. Brigiani, G. Formoso, M. J. Quon, and M. Montagnani Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H813 - H822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, G. Sullivan, and M. J. Quon Assessing the Predictive Accuracy of QUICKI as a Surrogate Index for Insulin Sensitivity Using a Calibration Model Diabetes, July 1, 2005; 54(7): 1914 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Koh, M. J. Quon, S. H. Han, J. Y. Ahn, D. K. Jin, H. S. Kim, D. S. Kim, and E. K. Shin Vascular and Metabolic Effects of Combined Therapy With Ramipril and Simvastatin in Patients With Type 2 Diabetes Hypertension, June 1, 2005; 45(6): 1088 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Karne, H. Chen, and M. J. Quon Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism: Response to Ascaso et al. Diabetes Care, May 1, 2004; 27(5): 1247 - 1248. [Full Text] [PDF]
|
|
|
|
|
|
L. S. Conwell, S. G. Trost, W. J. Brown, and J. A. Batch Indexes of Insulin Resistance and Secretion in Obese Children and Adolescents: A validation study Diabetes Care, February 1, 2004; 27(2): 314 - 319. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
