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Am J Physiol Endocrinol Metab 284: E778-E787, 2003. First published December 27, 2002; doi:10.1152/ajpendo.00128.2002
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Vol. 284, Issue 4, E778-E787, April 2003

Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion

Robert L. Dobbins1, Lidia S. Szczepaniak1, Weiguo Zhang1, and J. Denis McGarry1,2

Departments of 1 Internal Medicine and 2 Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9135

To assess the importance of the sympathetic nervous system in regulating body weight during prolonged leptin infusion, we evaluated food intake, body weight, and physical activity in conscious, unrestrained rats. Initial studies illustrated that prolonged intracerebroventricular (ICV) infusion of leptin enhanced substrate oxidation so that adipose tissue lipid stores were completely ablated, and muscle triglyceride and liver glycogen stores were depleted. After neonatal chemical sympathectomy, changes in weight and food intake were compared in groups of sympathectomized (SYM) and control (CON) adult animals during ICV infusion of leptin. CON animals lost 60 ± 9 g over 10 days vs. 25 ± 3 g in the SYM animals when food intake was matched between the two groups. Greater weight loss despite similar energy intake points to an important role of the sympathetic nervous system in stimulating energy expenditure during ICV leptin infusion by increasing the resting metabolic rate, since no differences in physical activity were observed between CON and SYM groups. In conclusion, activation of the SNS by leptin increases energy expenditure by augmenting the resting metabolic rate.

lipid oxidation; sympathetic nervous system; intracerebroventricular


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