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Am J Physiol Endocrinol Metab 284: E771-E777, 2003. First published December 10, 2002; doi:10.1152/ajpendo.00478.2002
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Vol. 284, Issue 4, E771-E777, April 2003

Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken

Anne Collin1,2, Mohammed Taouis1, Johan Buyse2, Ndey B. Ifuta4, Veerle M. Darras3, Pieter Van As2, Ramon D. Malheiros2, Vera M. B. Moraes2,5, and Eddy Decuypere2

1 Station de Recherches Avicoles, Institut National de la Recherche Agronomique, F-37380 Nouzilly, France; 2 Laboratory for Physiology of Domestic Animals, Department of Animal Production, Katholieke Universiteit Leuven, B-3001 Leuven and 3 Laboratory of Comparative Endocrinology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; 4 Département de Biologie, Institute Supérieur de la Gombe, Kinshasa/Gombe, République Démocratique du Congo; 5 Faculdade de Ciencas Agrárias e Veterinárias, Universidade Estadual Paulista-Jaboticabal, Departamento de Zootecnia, Jaboticabal-Sao Paulo, Brazil 14870 - 000

The aim of this study was to investigate the hormonal regulation of the avian homolog of mammalian uncoupling protein (avUCP) by studying the impact of thyroid hormones and insulin on avUCP mRNA expression in chickens (Gallus gallus). For 3 wk, chicks received either a standard diet (control group), or a standard diet supplemented with triiodothyronine (T3; T3 group) or with the thyroid gland inhibitor methimazole (MMI group). A fourth group received injections of the deiodinase inhibitor iopanoic acid (IOP group). During the 4th wk of age, all animals received two daily injections of either human insulin or saline solution. The results indicate a twofold overexpression of avUCP mRNA in gastrocnemius muscle of T3 birds and a clear downregulation (-74%) in MMI chickens compared with control chickens. Insulin injections had no significant effect on avUCP mRNA expression in chickens. This study describes for the first time induction of avUCP mRNA expression by the thermogenic hormone T3 in chickens and supports a possible involvement of avUCP in avian thermogenesis.

thyroid hormones; thermogenesis; muscle


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