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Am J Physiol Endocrinol Metab 284: E764-E770, 2003. First published December 10, 2002; doi:10.1152/ajpendo.00338.2002
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Vol. 284, Issue 4, E764-E770, April 2003

Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states

Magali Louis1, Jacques R. Poortmans2, Marc Francaux1, Eric Hultman3, Jacques Berré2, Nathalie Boisseau4, Vernon R. Young5, Kenneth Smith6, Wolfram Meier-Augenstein6, John A. Babraj6, Tom Waddell6, and Michael J. Rennie6

1 Université catholique de Louvain, 2 Université Libre de Bruxelles, Brussels 1200, Belgium; 3 Karolinska Institute, Stockholm 11440, Sweden; 4 Université de Poitiers, Poitiers 86034, France; 5 Massachusetts Institute of Technology, Cambridge, Massachusetts 02142; and 6 University of Dundee, Dundee DD1 4HN, Scotland

Dietary creatine supplementation is associated with increases in muscle mass, but the mechanism is unknown. We tested the hypothesis that creatine supplementation enhanced myofibrillar protein synthesis (MPS) and diminished muscle protein breakdown (MPB) in the fed state. Six healthy men (26 ± 7 yr, body mass index 22 ± 4 kg/m2) were studied twice, 2-4 wk apart, before and after ingestion of creatine (21 g/day, 5 days). We carried out two sets of measurements within 5.5 h of both MPS (by incorporation of [1-13C]leucine in quadriceps muscle) and MPB (as dilution of [1-13C]leucine or [2H5]phenylalanine across the forearm); for the first 3 h, the subjects were postabsorptive but thereafter were fed orally (0.3 g maltodextrin and 0.083 g protein · kg body wt-1 · h-1). Creatine supplementation increased muscle total creatine by ~30% (P < 0.01). Feeding had significant effects, doubling MPS (P < 0.001) and depressing MPB by ~40% (P < 0.026), but creatine had no effect on turnover in the postabsorptive or fed states. Thus any increase in muscle mass accompanying creatine supplementation must be associated with increased physical activity.

skeletal muscle; protein synthesis; protein breakdown


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