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1 Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110; and 2 Department of Nutrition and Dietetics, Harokopio University, 17671 Athens, Greece
We have previously
shown that sex and obesity independently affect basal very low density
lipoprotein (VLDL)-triglyceride (TG) kinetics. In the present study, we
investigated the effect of hyperglycemia-hyperinsulinemia on VLDL-TG
kinetics in lean and obese men and women (n = 6 in each group). VLDL-TG kinetics were measured during basal,
postabsorptive conditions and during glucose infusion (5.5 mg · kg
FFM
1 · min1) by using
[2H5]glycerol bolus injection in conjunction
with compartmental modeling analysis. Basal VLDL-TG secretion in plasma
was greater in obese than in lean men (7.8 ± 0.6 and 2.9 ± 0.4 µmol · l
plasma1 · min1;
P < 0.001) but was not different in lean and obese
women (5.0 ± 1.1 and 5.9 ± 1.1 µmol · l
plasma1 · min1).
Glucose infusion decreased the VLDL-TG secretion rate by ~50% in
lean and obese men and in lean women (to 1.5 ± 0.4, 4.0 ± 0.6, and 2.2 ± 0.4 µmol · l
plasma1 · min1,
respectively; all P < 0.05) but had no effect on the
VLDL-TG secretion rate in obese women (4.9 ± 1.0 µmol · l
plasma1 · min1).
These results demonstrate that both sex and adiposity affect the
regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG
production in both lean men and lean women; obesity is associated with
resistance to the glucose- and insulin-mediated suppression of
VLDL-TG secretion in women, but not in men.
hyperglycemia; coronary heart disease; hypertriglyceridemia
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