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Am J Physiol Endocrinol Metab 284: E708-E715, 2003. First published December 10, 2002; doi:10.1152/ajpendo.00411.2002
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Vol. 284, Issue 4, E708-E715, April 2003

VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity

Bettina Mittendorfer1, Bruce W. Patterson1, Samuel Klein1, and Labros S. Sidossis2

1 Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110; and 2 Department of Nutrition and Dietetics, Harokopio University, 17671 Athens, Greece

We have previously shown that sex and obesity independently affect basal very low density lipoprotein (VLDL)-triglyceride (TG) kinetics. In the present study, we investigated the effect of hyperglycemia-hyperinsulinemia on VLDL-TG kinetics in lean and obese men and women (n = 6 in each group). VLDL-TG kinetics were measured during basal, postabsorptive conditions and during glucose infusion (5.5 mg · kg FFM-1 · min-1) by using [2H5]glycerol bolus injection in conjunction with compartmental modeling analysis. Basal VLDL-TG secretion in plasma was greater in obese than in lean men (7.8 ± 0.6 and 2.9 ± 0.4 µmol · l plasma-1 · min-1; P < 0.001) but was not different in lean and obese women (5.0 ± 1.1 and 5.9 ± 1.1 µmol · l plasma-1 · min-1). Glucose infusion decreased the VLDL-TG secretion rate by ~50% in lean and obese men and in lean women (to 1.5 ± 0.4, 4.0 ± 0.6, and 2.2 ± 0.4 µmol · l plasma-1 · min-1, respectively; all P < 0.05) but had no effect on the VLDL-TG secretion rate in obese women (4.9 ± 1.0 µmol · l plasma-1 · min-1). These results demonstrate that both sex and adiposity affect the regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose- and insulin-mediated suppression of VLDL-TG secretion in women, but not in men.

hyperglycemia; coronary heart disease; hypertriglyceridemia


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