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Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110
The effects of obesity and weight
loss on lipoprotein kinetics were evaluated in six lean women [body
mass index (BMI): 21 ± 1 kg/m2] and seven women with
abdominal obesity (BMI: 36 ± 1 kg/m2). Stable isotope
tracer techniques, in conjunction with compartmental modeling, were
used to determine VLDL-triglyceride (TG) and apolipoprotein B-100
(apoB-100) secretion rates in lean women and in obese women before and
after 10% weight loss. VLDL-TG and VLDL-apoB-100 secretion rates were
similar in lean and obese women. Weight loss decreased the rate of
VLDL-TG secretion by ~40% (from 0.41 ± 0.05 to 0.23 ± 0.03 µmol · kg fat-free
mass
1 · min1;
P < 0.05). The relative decline in VLDL-TG produced
from nonsystemic fatty acids, derived from intraperitoneal and
intrahepatic TG, was greater (61 ± 7%) than the decline in
VLDL-TG produced from systemic fatty acids, predominantly derived from
subcutaneous TG (25 ± 8%; P < 0.05). Weight
loss did not affect VLDL-apoB-100 secretion rate. We conclude that
weight loss decreases the rate of VLDL-TG secretion in women with
abdominal obesity, primarily by decreasing the availability of
nonsystemic fatty acids. There is a dissociation in the effect of
weight loss on VLDL-TG and apoB-100 metabolic pathways that may affect
VLDL particle size.
lipoprotein; fatty acids; lipolysis
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