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Am J Physiol Endocrinol Metab 284: E453-E467, 2003; doi:10.1152/ajpendo.00463.2002
0193-1849/03 $5.00
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Vol. 284, Issue 3, E453-E467, March 2003

HISTORICAL PERSPECTIVE
A forty-year memoir of research on the regulation of glucose transport into muscle

John O. Holloszy

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

This historical review describes the research on the regulation of glucose transport in skeletal muscle conducted in my laboratory and in collaboration with a number of colleagues in other laboratories. This research includes studies of stimulation of glucose transport, GLUT4 translocation, and GLUT4 expression by exercise/muscle contractions, the role of Ca2+ in these processes, and the interactions between the effects of exercise and insulin. Among the last are the additive effects of insulin and contractions on glucose transport and GLUT4 translocation and the increases in muscle insulin sensitivity and responsiveness induced by exercise.




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