| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Max Planck Institute of Psychiatry, Department of Psychiatry, 80804 Munich, Germany
Ghrelin, an endogenous
ligand of the growth hormone (GH) secretagogue (GHS) receptor,
stimulates GH release, appetite, and weight gain in humans and rodents.
Synthetic GHSs modulate sleep electroencephalogram (EEG) and nocturnal
hormone secretion. We studied the effect of 4 × 50 µg of
ghrelin administered hourly as intravenous boluses between 2200 and
0100 on sleep EEG and the secretion of plasma GH, ACTH, cortisol,
prolactin, and leptin in humans (n = 7). After ghrelin
administration, slow-wave sleep was increased during the total night
and accumulated 
-wave activity was enhanced during the second half
of the night. Rapid-eye-movement (REM) sleep was reduced during the
second third of the night, whereas all other sleep EEG variables
remained unchanged. Furthermore, GH and prolactin plasma levels were
enhanced throughout the night, and cortisol levels increased during the
first part of the night (2200-0300). The response of GH to ghrelin
was most distinct after the first injection and lowest after the fourth
injection. In contrast, cortisol showed an inverse pattern of response.
Leptin levels did not differ between groups. Our data show a distinct action of exogenous ghrelin on sleep EEG and nocturnal hormone secretion. We suggest that ghrelin is an endogenous sleep-promoting factor. This role appears to be complementary to the already described effects of the peptide in the regulation of energy balance.
Furthermore, ghrelin appears to be a common stimulus of the
somatotropic and hypothalamo-pituitary-adrenocortical systems. It
appears that ghrelin is a sleep-promoting factor in humans.
growth hormone; adrenocorticotropic hormone; cortisol; prolactin; leptin; sleep endocrinology
This article has been cited by other articles:
|
|
 |
|
  R. D. Vorona Sleep, Sleep Disorders, and the Endocrine System ACCP Sleep Med Brd Rev, January 1, 2009; 4(0): 163 - 184. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tawadros, L.A. Salamonsen, E. Dimitriadis, and C. Chen Facilitation of decidualization by locally produced ghrelin in the human endometrium Mol. Hum. Reprod., July 1, 2007; 13(7): 483 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Szentirmai, L. Kapas, Y. Sun, R. G. Smith, and J. M. Krueger Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R510 - R517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Yannielli, P. C. Molyneux, M. E. Harrington, and D. A. Golombek Ghrelin Effects on the Circadian System of Mice J. Neurosci., March 14, 2007; 27(11): 2890 - 2895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Szentirmai, L. Kapas, and J. M. Krueger Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R575 - R585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Steiger Ghrelin and sleep-wake regulation Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R573 - R574. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Spiegel, K. Knutson, R. Leproult, E. Tasali, and E. V. Cauter Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes J Appl Physiol, November 1, 2005; 99(5): 2008 - 2019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T L Peeters Ghrelin: a new player in the control of gastrointestinal functions Gut, November 1, 2005; 54(11): 1638 - 1649. [Full Text] [PDF]
|
|
|
|
|
|
L. S. Farhy and J. D. Veldhuis Deterministic construct of amplifying actions of ghrelin on pulsatile growth hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1649 - R1663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Steiger Eating and sleeping--their relationship to ghrelin and leptin Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1031 - R1032. [Full Text] [PDF]
|
|
|
|
|
|
B. Bodosi, J. Gardi, I. Hajdu, E. Szentirmai, F. Obal Jr., and J. M. Krueger Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1071 - R1079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. van der Lely, M. Tschop, M. L. Heiman, and E. Ghigo Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin Endocr. Rev., June 1, 2004; 25(3): 426 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dzaja, M. A. Dalal, H. Himmerich, M. Uhr, T. Pollmacher, and A. Schuld Sleep enhances nocturnal plasma ghrelin levels in healthy subjects Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E963 - E967. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
