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Am J Physiol Endocrinol Metab 284: E148-E155, 2003. First published September 11, 2002; doi:10.1152/ajpendo.00079.2002
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Vol. 284, Issue 1, E148-E155, January 2003

Characterization of the portal signal in a nonsteady hyperglycemic state in conscious dogs

N. Ogihara1, S. Ebihara1, W. Kawamura1, M. Okamoto1, T. Sakai1, K. Takiguchi1, T. Morita1, R. Uchida1, Y. Matsuyama2, Y. Hayashi3, Y. Arakawa3, and M. Kikuchi1

1 Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation, Tokyo 160-0023; 2 Department of Health Science, Department of Biostatistics, Kyoto University School of Public Health, Kyoto 606-8501; and 3 Third Department of Internal Medicine, Nihon University, Tokyo 173-8610, Japan

To characterize the "portal signal" in a nonsteady hyperglycemic state, the kinetic relationship between net hepatic glucose balance (NHGB) and either hepatic glucose load (HGL) or plasma insulin level was determined during glucose infusion using a catheter technique in 36 conscious dogs. Glucose was infused intraportally (Po group) and peripherally (Pe group) at 39, 56, and 83 µmol · kg-1 · min-1 over 2 h. There was a linear relationship between mean NHGB and either mean HGL or plasma insulin levels at each rate in either delivery (HGL: Po r = 0.99, Pe r = 0.95; insulin: Po r = 99, Pe r = 0.79). The threshold levels for net hepatic glucose uptake were 3.8 and 11.7 mmol/l for plasma glucose and 65 and 392 pmol/l for plasma insulin, respectively. The slope of the regression line against the abscissa was four times larger in portal than in peripheral delivery (HGL: Po 0.20 vs. Pe 0.05, P < 0.05; insulin: Po 0.19 vs. Pe 0.04, P < 0.05). These results suggest that the portal signal overrules the threshold of glucose for hepatic uptake by increasing hepatic extraction rate in a nonsteady hyperglycemic state.

glucose delivery route; hepatic glucose load; insulin dependency; hepatic glucose uptake


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