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Am J Physiol Endocrinol Metab 284: E120-E128, 2003. First published September 24, 2002; doi:10.1152/ajpendo.00363.2002
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Vol. 284, Issue 1, E120-E128, January 2003

Effects of an oral androgen on muscle and metabolism in older, community-dwelling men

E. Todd Schroeder1, Atam Singh2, Shalender Bhasin2, Thomas W. Storer2, Colleen Azen1, Tina Davidson2, Carmen Martinez1, Indrani Sinha-Hikim2, S. Victoria Jaque1, Michael Terk1, and Fred R. Sattler1

1 Departments of Medicine, Radiology, and Biokinesiology, Keck School of Medicine, University of Southern California, Los Angeles 90033; and 2 Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University School of Medicine, Los Angeles, California 90275

To determine whether oxymetholone increases lean body mass (LBM) and skeletal muscle strength in older persons, 31 men 65-80 yr of age were randomized to placebo (group 1) or 50 mg (group 2) or 100 mg (group 3) daily for 12 wk. For the three groups, total LBM increased by 0.0 ± 0.6, 3.3 ± 1.2 (P < 0.001), and 4.2 ± 2.4 kg (P < 0.001), respectively. Trunk fat decreased by 0.2 ± 0.4, 1.7 ± 1.0 (P = 0.018), and 2.2 ± 0.9 kg (P = 0.005) in groups 1, 2, and 3, respectively. Relative increases in 1-repetition maximum (1-RM) strength for biaxial chest press of 8.2 ± 9.2 and 13.9 ± 8.1% in the two active treatment groups were significantly different from the change (-0.8 ± 4.3%) for the placebo group (P < 0.03). For lat pull-down, 1-RM changed by -0.6 ± 8.3, 8.8 ± 15.1, and 18.4 ± 21.0% for the groups, respectively (1-way ANOVA, P = 0.019). The pattern of changes among the groups for LBM and upper-body strength suggested that changes might be related to dose. Alanine aminotransferase increased by 72 ± 67 U/l in group 3 (P < 0.001), and HDL-cholesterol decreased by -19 ± 9 and -23 ± 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men.

oxymetholone; androgen therapy; older men; sarcopenia; lean body mass


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