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expression in, and release from, contracting
human skeletal muscle
1 Copenhagen Muscle Research Centre and 2 Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; and 3 Department of Physiology, The University of Melbourne, Parkville, Victoria xxxx, Australia
The aim of the present study was to
examine whether IL-6 and TNF-
are expressed in, and released from,
human skeletal muscle during exercise. We hypothesized that the
skeletal muscle will release IL-6, but not TNF-, during exercise
because of previous observations that TNF- negatively affects
glucose uptake in skeletal muscle. Six healthy, male subjects performed
180 min of two-legged knee-extensor exercise. Muscle samples were
obtained from the vastus lateralis of one limb. In addition,
blood samples were obtained from a femoral artery and vein. Plasma was
analyzed for IL-6 and TNF-. We detected both IL-6 and TNF- mRNA
in resting muscle samples, and whereas IL-6 increased
(P < 0.05) ~100-fold throughout exercise, no
significant increase in TNF- mRNA was observed. Arterial plasma
TNF- did not increase during exercise. Furthermore, there was no net
release of TNF- either before or during exercise. In contrast, IL-6
increased throughout exercise in arterial plasma, and a net IL-6
release from the contracting limb was observed after 120 min of
exercise (P < 0.05).
cytokines; interleukins; exercise; metabolism; endocrine system
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