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Am J Physiol Endocrinol Metab 283: E1266-E1271, 2002. First published August 13, 2002; doi:10.1152/ajpendo.00227.2002
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Vol. 283, Issue 6, E1266-E1271, December 2002

Adiponectin is stimulated by adrenalectomy in ob/ob mice and is highly correlated with resistin mRNA

Hideo Makimura1,2, Tooru M. Mizuno1,2, Hugo Bergen3, and Charles V. Mobbs1,2

1 Neurobiology of Aging Laboratories, Fishberg Center for Neurobiology and 2 Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029; and 3 Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3

Plasma levels of the adipocyte product adiponectin, a putative insulin-sensitizing agent, are reduced in obesity, whereas plasma levels of resistin, an agent that some believe to confer insulin resistance, are thought to increase with obesity. Because adrenalectomy can increase insulin sensitivity, we hypothesized that adrenalectomy would increase expression of adiponectin and decrease expression of resistin. Therefore, we measured adiponectin mRNA, adiponectin peptide, and resistin mRNA in adrenalectomized ob/ob mice. Adrenalectomy restored adiponectin expression in ob/ob mice to wild-type levels and stimulated adiponectin peptide to above wild-type levels. Surprisingly, expression of adiponectin and resistin was highly positively correlated even after statistical removal of effects of insulin, glucose, and adiposity. In addition, adiponectin and resistin expression were also highly correlated in diet-induced obese mice. The data support a role for adiponectin in mediating some effects of adrenalectomy on insulin sensitivity.

AdipoQ; adipocyte complement-related protein of 30 kDa; insulin resistance; glucocorticoids; leptin; messenger ribonucleic acid


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