AJP - Endo Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 283: E1105-E1112, 2002; doi:10.1152/ajpendo.00337.2002
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, Z.
Right arrow Articles by Barrett, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, Z.
Right arrow Articles by Barrett, E. J.
Vol. 283, Issue 6, E1105-E1112, December 2002

INVITED REVIEW
Human protein metabolism: its measurement and regulation

Zhenqi Liu and Eugene J. Barrett

Division of Endocrinology and Metabolism, Department of Internal Medicine, and the General Clinical Research Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908

The body's protein mass not only provides architectural support for cells but also serves vital roles in maintaining their function and survival. The whole body protein pool, as well as that of individual tissues, is determined by the balance between the processes of protein synthesis and degradation. These in turn are regulated by interactions among hormonal, nutritional, neural, inflammatory, and other influences. Prolonged changes in either the synthetic or degradative processes (or both) that cause protein wasting increase morbidity and mortality. The application of tracer kinetic methods, combined with measurements of the activity of components of the cellular signaling pathways involved in protein synthesis and degradation, affords new insights into the regulation of both protein synthesis and breakdown in vivo. These insights, including those from studies of insulin, insulin-like growth factor I, growth hormone, and amino acid-mediated regulation of muscle and whole body protein turnover, provide opportunities to develop and test therapeutic approaches with promise to minimize or prevent these adverse health consequences.

protein synthesis; proteolysis; insulin; insulin-like growth factor I; growth hormone; amino acids


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. Q. Nuttall, K. Schweim, H. Hoover, and M. C. Gannon
Metabolic effect of a LoBAG30 diet in men with type 2 diabetes
Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E786 - E791.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. L. D. Riis, J. O. L. Jorgensen, S. Gjedde, H. Norrelund, A. G. Jurik, K. S. Nair, P. Ivarsen, J. Weeke, and N. Moller
Whole body and forearm substrate metabolism in hyperthyroidism: evidence of increased basal muscle protein breakdown
Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1067 - E1073.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Z. Liu, G. Li, S. R. Kimball, L. A. Jahn, and E. J. Barrett
Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle
Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E275 - E281.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Faridi, J. Fawcett, L. Wang, and R. A. Roth
Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E964 - E972.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online